Evidence map›Paper›PMID 42639658›Full record

ArticleCirculation research2026

Regulated HSPG Signaling Directs Epicardial Behavior to Support Cardiac Formation.

Andia N Redpath, Irina-Elena Lupu, Louis Haffreingue, Quang M Dang, Ian R McCracken, Tamara Carsana, Toin H van Kuppevelt, Joaquim Miguel Vieira, Nicola Smart

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In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andia N RedpathDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).ORCID 0000-0002-3620-4983
Irina-Elena LupuDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).ORCID 0000-0002-0869-8525
Louis HaffreingueDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).
Quang M DangDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).ORCID 0009-0000-7083-8560
Ian R McCrackenDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).ORCID 0000-0001-8806-548X
Tamara CarsanaDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).ORCID 0009-0004-3387-3171
Toin H van KuppeveltDepartment of Biochemistry, Radboud University Medical Center, Nijmegen, the Netherlands (T.H.v.K.).ORCID 0000-0002-7028-6783
Joaquim Miguel VieiraSchool of Cardiovascular & Metabolic Medicine & Sciences, King's College London, United Kingdom (J.M.V.).ORCID 0000-0003-2023-6304
Nicola SmartDepartment of Physiology, Anatomy & Genetics, Institute of Developmental and Regenerative Medicine, University of Oxford, United Kingdom (A.N.R., I.-E.L., L.H., Q.M.D., I.R.M., T.C., N.S.).ORCID 0000-0002-3501-7254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPathways controlling cardiac cell behavior share a common dependency on heparan sulfate proteoglycans (HSPGs), which tightly regulate signaling at extracellular locations. This signaling is essential for cardiac development, yet how HSPGs are regulated in the forming heart is unknown. The epicardium is a rich source of HSPG-dependent signaling and cellular progenitors. We hypothesized that extracellular heparan sulfate modifiers, 6-

methodsWe used single-cell RNA sequencing, microscopy, and flow cytometry-based single-molecule RNA in situ hybridization (ISH) to systematically profile 6-

resultsDespite identical function, we find that

conclusionsOur study highlights, for the first time, essential fine-tuning of HSPG-dependent signaling to modulate key processes in heart formation, offering potential insights for therapeutically targeting congenital heart disease and enhancing epicardial proregenerative behaviors.

Indexed as

HeartHeparan Sulfate ProteoglycansPericardiumAnimalsGene Expression Regulation, DevelopmentalMiceMice, KnockoutSignal TransductionSulfatasesSulfotransferasesHeparan Sulfate ProteoglycansSulf1 protein, mouseSulfatasesSulfotransferasesepithelial-mesenchymal transitionheartheparan sulfate proteoglycansmorphogenesissulfatasestransforming growth factors

Identifiers

PMID42639658
PMCPMC13608351

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.