Evidence map›Paper›PMID 42639656›Full record

ArticleCirculation2026

Dual-Target Cardiac Regeneration: Controllable

Bingjun Lu, Wujian Liu, Ziyan Ge, Jiamin Zou, Yidan Xu, Zhuo Zhang, Lanlan Ma, Jiangcheng Shu, Yuyao Liu, Cong Chen and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Bingjun Lu *Department of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.ORCID 0000-0001-7360-2326
Wujian Liu *Department of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Ziyan GeDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Jiamin ZouDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Yidan XuDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.ORCID 0009-0007-8495-4934
Zhuo ZhangState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan, China (Z.Z., D.Z.).ORCID 0009-0001-4734-1561
Lanlan MaDepartment of Geriatrics, Chongqing Key Laboratory of Aging and Regeneration Medicine, Southwest Hospital of Army Medical University (Third Military Medical University), China (B.L., W.L., Z.G., J.Z., L.M., J.S., Y.L., C.C., J.Z., S.T., W.E.W.).
Jiangcheng ShuDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Yuyao LiuDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Cong ChenDepartment of Geriatrics, Chongqing Key Laboratory of Aging and Regeneration Medicine, Southwest Hospital of Army Medical University (Third Military Medical University), China (B.L., W.L., Z.G., J.Z., L.M., J.S., Y.L., C.C., J.Z., S.T., W.E.W.).
Juanjuan ZhengDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Jia LiDepartment of Medical Genetics, College of Basic Medical Science (J.L.), Army Medical University (Third Military Medical University), Chongqing, China.
Zhen LiuDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.ORCID 0000-0001-7186-4816
Sisi TianDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.
Xuemei ChenDepartment of Ultrasound, Southwest Hospital of Army Medical University (Third Military Medical University), Chongqing, China (X.C., Y.G.).
Yanli GuoDepartment of Ultrasound, Southwest Hospital of Army Medical University (Third Military Medical University), Chongqing, China (X.C., Y.G.).ORCID 0009-0002-4648-148X
Donghui ZhangState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan, China (Z.Z., D.Z.).
Steven R HouserDepartment of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (S.R.H.).
Wei Eric WangDepartment of Cardiology, Xinqiao Hospital (B.L., W.L., Z.G., J.Z., Y.X., J.S., Y.L., J.Z., Z.L., S.T., W.E.W.), Army Medical University (Third Military Medical University), Chongqing, China.ORCID 0000-0002-8315-2362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial infarction can cause a massive loss of functional cardiomyocytes, yet effective strategies to stimulate cardiac regeneration remain lacking. A key barrier to adult cardiomyocyte proliferation appears to be cytokinesis inhibition. This study aimed to determine whether combining proliferation stimulators with the removal of cytokinesis-inhibitory constraints could unlock regenerative potential after myocardial infarction.

methodsTranscriptomic profile from 5 regeneration models, including

resultsIntegrative multimodel analysis revealed a dual regulatory control system for cardiomyocyte proliferation, along with key associated genes and transcriptional regulators.

conclusionsThis work documents a dual-control paradigm of cardiomyocyte proliferation and establishes

Indexed as

CytokinesisMyocardial InfarctionMyocytes, CardiacRegenerationAnimalsCell ProliferationMaleMiceMice, Inbred C57BLMice, Transgeniccytokinesismultiomicsmyocardial infarctionmyocytes, cardiacsingle-cell gene expression analysis

Identifiers

PMID42639656
PMCPMC13668044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.