Evidence map›Paper›PMID 42639637›Full record

ArticleInternational IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering2025

A Miniature Wireless Device for Closed-Loop Auditory Sleep Modulation.

William Lee, Savanna Blade, Yuhan Hou, Amelia McIver, Runtian Yang, Xilin Liu, Andrew G Richardson

Abstract read
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In one paragraph

Article in International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

William LeeDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States of America.
Savanna BladeDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
Yuhan HouDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
Amelia McIverDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States of America.
Runtian YangDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
Xilin LiuDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
Andrew G RichardsonDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States of America.

Funding

A wireless closed-loop sleep modulation system-on-chipR01NS129738 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrew Garmory Richardson · 2023 to 2026
$1.7M
NINDS NIH HHS R01 NS129738
6 · The paper itself

Abstract

Both sleep research and treatment of common sleep disorders can benefit from targeted modulation of sleep circuits. Noninvasive stimulation through the auditory pathway has proven to be an effective method for neuromodulation during sleep, particularly when timed to ongoing rhythms using a closed-loop system. However, such systems are not widely available to the research or clinical communities. Technical demands include real-time sleep scoring, phase estimation, and low-latency auditory feedback. Our goal is to develop a robust, easy-to-use, wireless, programmable, closed-loop sleep modulation device suitable for subjects ranging from mice to humans and for use outside of a sleep lab environment. Here, we present a prototype: a battery-powered, flex-rigid printed-circuit board with off-the-shelf components for polysomnography data acquisition and wireless transmission, as well as configurable closed-loop control through a Python graphical user interface. Performance was quantified through a series of experiments in freely behaving rats.

Indexed as

neuromodulationrodentsensory feedbacksleepwearable

Identifiers

PMID42639637
PMCPMC13502937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.