ArticleCureus2026
Profound Hypothyroidism as a Reversible Cause of Severe Low-Density Lipoprotein Cholesterol (LDL-C) Elevation: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Thyroid hormone plays a central role in regulating lipid metabolism. In states of profound hypothyroidism, impaired triiodothyronine (T3)-mediated regulation of hepatic LDL (low-density lipoprotein) receptor expression results in decreased clearance of apolipoprotein B-containing lipoproteins. These physiologic disturbances can lead to substantial low-density lipoprotein cholesterol (LDL-C) elevation, which can mimic primary genetic lipid disorders and complicate the clinical evaluation of severe hypercholesterolemia. Herein, we describe a patient with autoimmune thyroid disease status post total thyroidectomy who demonstrated marked, reproducible LDL-C elevations during periods of profound hypothyroidism, with substantial improvement upon restoration of euthyroidism. These fluctuations occurred in the absence of lipid-lowering therapy. This case highlights the importance of assessing thyroid function in patients with severe LDL-C elevation. Recognition and treatment of hypothyroidism can substantially improve lipid abnormalities and reveal a reversible endocrine-mediated contributor to marked hypercholesterolemia.
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