ArticleCancer management and research2026
Expression of EMT-Related Markers and CD133 in Non-Small Cell Lung Cancer: Associations with Clinicopathological Features and Prognosis.
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: This study aimed to investigate the expression of CD133 and epithelial-mesenchymal transition EMT-related factors (Snail, E-cadherin) and their prognostic and clinicopathological significance in non-small cell lung cancer (NSCLC). Methods: A total of 150 paired NSCLC and adjacent normal tissue samples were collected. Immunohistochemistry was used to detect CD133, Snail, and E-cadherin expression. Clinicopathological correlations were analyzed statistically. The Kaplan-Meier method was used for survival analysis, and Spearman correlation was applied to evaluate the associations among protein expressions. Results: NSCLC tissues exhibited significantly elevated Snail and CD133 expression and reduced E-cadherin expression compared with adjacent tissues (P<0.05). Snail, E-cadherin, and CD133 expression were closely correlated with tumor differentiation, lymph node metastasis, and TNM stage, with E-cadherin also associated with tumor size (P<0.05). CD133 was positively correlated with Snail (r=0.377, P<0.001) and negatively correlated with E-cadherin (r=-0.448, P<0.001). High Snail and CD133 expression indicated poorer survival, while high E-cadherin expression predicted favorable prognosis (P<0.05). Combined expression of these biomarkers effectively predicted NSCLC patients survival. Conclusion: CD133 and EMT markers are closely linked to NSCLC progression and invasion. Combined detection of Snail, E-cadherin, and CD133 provides a reliable biomarker panel for precise prognostic evaluation of NSCLC patients.
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