ReviewClinical, cosmetic and investigational dermatology2026
Coordinated Regulation of Signaling Pathways by Stem Cell-Derived Extracellular Vesicles: A Promising Strategy Against Skin Photoaging.
Review in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet (UV) radiation accelerates skin aging by promoting collagen breakdown, inflammation, and oxidative stress. Recent studies have identified stem cell-derived extracellular vesicles (EVs) as promising agents for treating photoaging due to their ability to carry bioactive molecules, including microRNAs, cytokines, and growth factors. These EVs mitigate UV-induced skin damage by modulating multiple signaling pathways, such as TGF-β/Smad, MAPK/AP-1, NF-κB, and SIRT1, resulting in decreased matrix metalloproteinase (MMPs) activity, reduced inflammatory cytokines, and enhanced collagen synthesis. Nevertheless, the therapeutic effects of EVs vary depending on their stem cell source, each exhibiting distinct biomolecular profiles and specific pathway interactions. Current evidence is mainly derived from in vitro or subcutaneous administration models; the feasibility of topical delivery which is more practical for clinical application remains to be determined due to skin barrier penetration challenges. Despite their potential, significant challenges remain, including diverse EV compositions, the absence of standardized isolation protocols and difficulties in large-scale production. Addressing these issues through targeted mechanistic research and optimized delivery strategies will facilitate the development of precise and effective EVs-based therapies for skin photoaging. Compared with existing reviews, we systematically summarize the crosstalk among multiple photoaging-related signaling pathways and the source-dependent functional heterogeneity of stem cell-derived EVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.