Evidence map›Paper›PMID 42639497›Full record

ArticleNeuroglia (Basel, Switzerland)2023

Modest Reduction in CAG Repeat Length Rescues Motor Deficits but Not Purkinje Cell Pathology and Gliosis in Spinocerebellar Ataxia Type 1 Mice.

Stephen Gilliat, Juao-Guilherme Rosa, Genevieve Benjamin, Kaelin Sbrocco, Wensheng Lin, Marija Cvetanovic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroglia (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephen GilliatDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-8952-6417
Juao-Guilherme RosaDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-7452-8313
Genevieve BenjaminDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Kaelin SbroccoDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Wensheng LinDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Marija CvetanovicDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.

Funding

Etiology of cognitive decline in Spinocerebellar ataxia type 1R01NS109077 · NINDS · UNIVERSITY OF MINNESOTA · PI Marija Cvetanovic, TIMOTHY J EBNER · 2020 to 2026
$2.4M
Understanding cellular and molecular mechanisms of neurodegenerationR01NS107387 · NINDS · UNIVERSITY OF MINNESOTA · PI CVETANOVIC, MARIJA · 2018 to 2021
$1.3M
NINDS NIH HHS R01 NS107387NINDS NIH HHS R01 NS109077
6 · The paper itself

Abstract

Spinocerebellar ataxia type 1 (SCA1) is a fatal, dominantly inherited neurodegenerative disease caused by the expansion of CAG repeats in the

Indexed as

astrogliaATAXIN-1cerebellumneurodegenerationneuroprotectivenuclear factor kappa b

Identifiers

PMID42639497
PMCPMC13501978

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.