Evidence map›Paper›PMID 42639465›Full record

ArticleCase reports in pediatrics2026

Resolution of Refractory Chylous Effusions With Targeted MEK Inhibition in NRAS Q61R-Driven Kaposiform Lymphangiomatosis: A Case Report.

Georgia Brown, Sarah McNab, Susan Keogh, John Massie, Lucas Eastaugh, Lydia Pathmanathan, Monique Bertinetti, Michael Sullivan, Lisa Orme, Thomas Cloney and 7 more

Abstract read
In one paragraph

Article in Case reports in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Georgia BrownPediatric Intensive Care Unit, The Royal Children's Hospital, Melbourne, Victoria, Australia, rch.org.au.ORCID https://orcid.org/0009-0004-0401-6023
Sarah McNabMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.
Susan KeoghThe Department of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia, rch.org.au.
John MassieMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0003-1008-0967
Lucas EastaughMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0002-1378-3230
Lydia PathmanathanThe Department of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia, rch.org.au.ORCID https://orcid.org/0000-0002-2524-5667
Monique BertinettiThe University of Melbourne, Melbourne, Victoria, Australia, unimelb.edu.au.ORCID https://orcid.org/0000-0002-3883-1243
Michael SullivanMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.
Lisa OrmeMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0002-9398-6977
Thomas CloneyMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0002-0210-1409
Natasha J BrownMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.
Tiong Y TanMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0001-8455-7778
Rebecca QuinMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0009-0003-8589-6909
Mark PertileMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0001-8363-2879
Anna MoonMedical Imaging Department, The Royal Children's Hospital, Melbourne, Victoria, Australia, rch.org.au.
Elhamy BekhitMedical Imaging Department, The Royal Children's Hospital, Melbourne, Victoria, Australia, rch.org.au.ORCID https://orcid.org/0000-0003-1717-3648
Tony PeningtonMurdoch Children's Research Institute, Melbourne, Victoria, Australia, mcri.edu.au.ORCID https://orcid.org/0000-0002-3254-8623

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Kaposiform lymphangiomatosis (KLA) is a rare and aggressive lymphatic anomaly characterised by chylous effusions, respiratory failure and poor prognosis. Diagnosis is often challenging and delayed due to the mosaic distribution of causative somatic mutations. Case Presentation: A previously well four-year-old girl presented with pleural and pericardial effusions and methicillin-sensitive Conclusion: This case highlights the diagnostic challenges of complex lymphatic anomalies, demonstrates the utility of cell-free DNA analysis from effusions in identifying pathogenic somatic variants and underscores the therapeutic potential of targeted MEK inhibition in NRAS Q61R-driven KLA.

Indexed as

case reportchylothoraxkaposiform lymphangiomatosisMEK inhibitorNRAS mutationtrametinib

Identifiers

PMID42639465
PMCPMC13501887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.