ReviewCureus2026
Platelet Concentrates in Periodontal Regeneration: A Review of Current Evidence and Clinical Perspectives.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a chronic inflammatory disease characterized by irreversible destruction of the periodontal ligament, cementum, and alveolar bone, making true periodontal regeneration a significant therapeutic challenge. Autologous platelet concentrates have emerged as promising biological adjuncts because they provide a fibrin scaffold enriched with platelets, leukocytes, and growth factors that promote angiogenesis, cell proliferation, extracellular matrix synthesis, and wound healing. This review summarizes the biological basis, classification, mechanisms of action, and current clinical evidence regarding platelet-rich plasma (PRP), platelet-rich fibrin (PRF), advanced platelet-rich fibrin (A-PRF), injectable platelet-rich fibrin (i-PRF), and titanium-prepared platelet-rich fibrin (T-PRF) in periodontal regeneration. Current evidence indicates that PRF is the most extensively investigated preparation and demonstrates consistent improvements in probing pocket depth, clinical attachment level, and radiographic bone fill, particularly in periodontal intrabony defects when used as an adjunct to open flap debridement or bone grafting; a recent network meta-analysis reported statistically significant standardized improvements in all three outcomes favoring PRF-based therapy. Evidence supporting the use of platelet concentrates in furcation defects, gingival recession, periodontal plastic surgery, and extraction socket preservation is encouraging but remains limited by heterogeneity in study design and preparation protocols. Overall, platelet concentrates represent valuable adjuncts to regenerative periodontal therapy; however, standardized preparation methods and well-designed multicenter randomized controlled trials are required to establish the comparative effectiveness of newer platelet concentrate preparations and optimize their clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.