Evidence map›Paper›PMID 42639416›Full record

ArticleRSC advances2026

Crosslinking strategies govern the morphology and biological performance of decellularized extracellular matrix particle-tyramine-modified hyaluronic acid hydrogels.

Jiangyao Xu, Jacek K Wychowaniec, Matteo D'Este, Nan Jiang, Songsong Zhu, Sibylle Grad, Jeroen Geurts, Zhen Li

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiangyao XuAO Research Institute Davos Davos Platz Switzerland zhen.li@aofoundation.org.ORCID https://orcid.org/0000-0003-4647-3906
Jacek K WychowaniecAO Research Institute Davos Davos Platz Switzerland zhen.li@aofoundation.org.ORCID https://orcid.org/0000-0002-6597-5242
Matteo D'EsteAO Research Institute Davos Davos Platz Switzerland zhen.li@aofoundation.org.ORCID https://orcid.org/0000-0002-0424-8172
Nan JiangState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu China.ORCID https://orcid.org/0000-0001-9221-9568
Songsong ZhuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu China.
Sibylle GradAO Research Institute Davos Davos Platz Switzerland zhen.li@aofoundation.org.ORCID https://orcid.org/0000-0001-9552-3653
Jeroen GeurtsLausanne University Hospital Lausanne Switzerland.ORCID https://orcid.org/0000-0002-4367-4641
Zhen LiAO Research Institute Davos Davos Platz Switzerland zhen.li@aofoundation.org.ORCID https://orcid.org/0000-0002-9754-6389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decellularized extracellular matrix (dECM) particle-based hydrogels hold promise for cartilage repair. Due to its chondropermissive properties, tuneable viscoelastic profile, and the potential to form covalent bonds with ECM proteins, tyramine-modified hyaluronic acid (THA) is an ideal candidate as a binder for dECM particles. However, the incorporation of the dECM particles into a viscoelastic hydrogel may interfere with its crosslinking. The goal of this study was to compare two crosslinking methods: (1) horseradish peroxidase/Eosin (HRP/Eo) with H

Identifiers

PMID42639416
PMCPMC13501466

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.