ArticleERJ open research2026
Prognostic value of long-term trajectory linearity in rapid lung function decline.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background: Rapid lung function decline has been identified as a risk factor for poor prognosis. However, among rapid decliners, the prognostic significance of the linearity of lung function trajectory remains unclear. Methods: We used the Ansan-Ansung cohort, a population-based prospective cohort study. We analysed trajectory patterns using consecutive lung function measurements over 12 years. Rapid lung function decline was defined as the annual forced expiratory volume in 1 s decline of >60 mL·year Results: 4809 individuals were followed-up for a median of 8.8 years, and 278 (5.8%) individuals died. Rapid decliners with linear trajectory had an increased risk of mortality compared with non-rapid decliners with linear trajectory (adjusted hazard ratio (aHR) 1.74, 95% CI 1.22-2.46). However, among individuals with nonlinear trajectory, the mortality risk was not significantly increased, even among rapid decliners (aHR 0.99, 95% CI 0.59-1.68). Conclusion: Among rapid decliners, linear trajectory was associated with a higher mortality risk. Trajectory linearity may therefore be a useful prognostic marker in this population.
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