ReviewFrontiers in endocrinology2026
The multisystem impact of perimenopausal hormonal fluctuations on chronic disease risk.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Hormonal shifts during menopause are crucial to women's health, characterized by a reduction in estrogen levels and an elevation in circulating androgen, which may result from either natural or surgical menopause. This review synthesizes current knowledge on the multifaceted mechanisms by which menopausal hormonal fluctuations reshape systemic health span. This review synthesizes current knowledge of the complex mechanisms between hormonal changes and immune cell interactions, highlighting how these relationships can influence disease risk during the menopausal transition. We also emphasize how these neuroendocrine-immune-microbial disruptions facilitate the pathogenesis of neurodegenerative disorders, cardiovascular diseases, osteoporosis and the evolution of tumorigenic microenvironments. Finally, we discuss key challenges and future research directions in related research with goal of informing novel strategies to prevent and treat menopause-related diseases.
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