Evidence map›Paper›PMID 42639349›Full record

ReviewFrontiers in plant science2026

Cytokinin derivatives as tools to enhance plant stress resilience.

Jan F Humplík, Thomas Schmülling, Martin Hönig

Abstract readReview
In one paragraph

Review in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jan F HumplíkDepartment of Chemical Biology, Faculty of Science, Palacký University, Olomouc, Czechia.
Thomas SchmüllingInstitute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Berlin, Germany.
Martin HönigDepartment of Chemical Biology, Faculty of Science, Palacký University, Olomouc, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokinins (CKs) are key regulators of plant growth and development. Recently, CKs have been increasingly recognized to have additional roles as modulators of plant adaptation to abiotic and biotic stresses. A large part of CK action in stress adaptation can be attributed to the promotion of antioxidative defense mechanisms. However, the contributions of CKs to stress tolerance can be complex and sometimes contradictory, as both increased and decreased CK signaling can enhance stress resilience depending on the context, a phenomenon referred to as the "cytokinin paradox". In addition, some effects of exogenously applied classical CKs, including inhibition of root elongation and stimulation of stomatal opening, may become detrimental under severe stress. Recent research has therefore focused on developing advanced CK-derived compounds that selectively enhance stress tolerance but possess reduced classical growth-regulatory activities of CKs. These advanced derivatives, including

Indexed as

abiotic stressbiotic stresscytokinincytokinin derivativescytokinin paradoxplant stress response

Identifiers

PMID42639349
PMCPMC13501151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.