Evidence map›Paper›PMID 42639291›Full record

ArticleMedComm2026

Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone.

Wei Wu, Chun-Xiu Gong, Jie Mei, Ling Hou, Yan Liang, Yan-Qin Ying, Feng Ye, Ge-Hang Ju, Hui-Xiang Tian, Nan Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei WuDepartment of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China.
Chun-Xiu GongDepartment of Endocrinology Genetics and Metabolism Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health Beijing China.
Jie MeiTianfu Jincheng Laboratory Chengdu China.ORCID https://orcid.org/0000-0002-8221-199X
Ling HouDepartment of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China.
Yan LiangDepartment of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China.
Yan-Qin YingDepartment of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China.
Feng YeDepartment of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China.
Ge-Hang JuInstitute of Big Data, Central South University Changsha China.
Hui-Xiang TianTianfu Jincheng Laboratory Chengdu China.ORCID https://orcid.org/0009-0007-3632-636X
Nan YangCenter of Clinical Pharmacology Third Xiangya Hospital, Central South University Changsha China.
Yun QinDepartment of Radiology West China Hospital, Sichuan University Chengdu China.
Dongsheng OuyangDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha China.
Xiaoping LuoDepartment of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long-acting PEGylated recombinant human growth hormone (PEG-rhGH) formulations have been developed to reduce injection frequency and improve adherence and quality of life. However, guidance on switching between short-acting and long-acting regimens during treatment and biomarker-driven precision dose-conversion strategies remains lacking in real-world clinical practice. Therefore, this study analyzed data from two populations comprising healthy adult male subjects (

Indexed as

dose switchinggrowth hormone deficiencyPEG‐rhGHPK/PD modelrhGH

Identifiers

PMID42639291
PMCPMC13501104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.