Evidence map›Paper›PMID 42639283›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2026

KSHV Seropositivity Associates With Impaired Immune Reconstitution in Virally Suppressed HIV.

Xiaowu Wang, Xiaoyu Fang, Tuantuan Li, Xinqi Geng, Yan Liu, Shuheng Wang, Dong Wu, Yilang Zhu, Linding Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. KSHV Seropositivity Associates With Impaired Immune Reconstitution in Virally Suppressed HIV.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaowu WangDepartment of Clinical Laboratory, The Second People's Hospital of Fuyang City, Fuyang, Anhui, China.
Xiaoyu FangDepartment of Pharmacy, Jieshou City People's Hospital, Fuyang, Anhui, China.
Tuantuan LiDepartment of Clinical Laboratory, The Second People's Hospital of Fuyang City, Fuyang, Anhui, China.
Xinqi GengAnhui Provincial Key Laboratory of Zoonoses, Department of Microbiology and Parasitology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.
Yan LiuAnhui Provincial Key Laboratory of Zoonoses, Department of Microbiology and Parasitology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.
Shuheng WangSchool of Mental Health and Psychology, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.
Dong WuSchool of Public Health, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.
Yilang ZhuDepartment of Clinical Laboratory, The Second People's Hospital of Fuyang City, Fuyang, Anhui, China.
Linding WangAnhui Provincial Key Laboratory of Zoonoses, Department of Microbiology and Parasitology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0000-0001-6877-5791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Kaposi's sarcoma-associated herpesvirus (KSHV) seropositivity is prevalent in people with HIV (PWH), yet its association with immune reconstitution during long-term ART remains unclear. Methods: In this retrospective cohort study, we reviewed the records of 209 virally suppressed PWH (VL < 50 copies/mL) after ≥ 2 years of ART. Participants were stratified based on their KSHV serostatus (IgG+). Data on immune parameters were extracted from laboratory reports corresponding to the 2-year post-ART time point. Results: KSHV seropositive individuals exhibited significantly lower CD4 Conclusion: KSHV seropositivity correlates with impaired immune reconstitution in virally suppressed PWH. CD4

Indexed as

CD4+ lymphocyte countcombined diagnostic modelHIVIL-6immune reconstitutionKSHV

Identifiers

PMID42639283
PMCPMC13501123

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.