Evidence map›Paper›PMID 42639247›Full record

ArticleMedComm2026

Transcriptional Profiling of Growth Hormone-Secreting Pituitary Adenoma Stem-Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications.

LinHao Yuan, Hao Yang, BaoWang Li, Huimin Sui, Peiliang Li, Xu Wang, Jiang Li, Guijun Jia, Zhaohui Zhu, Deling Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

LinHao YuanDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Hao YangDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
BaoWang LiDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Huimin SuiDepartment of Nuclear Medicine State Key Laboratory of Complex Severe and Rare Diseases Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing China.
Peiliang LiDepartment of Neurosurgery Beijing Ditan Hospital Capital Medical University Beijing China.
Xu WangDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Jiang LiDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Guijun JiaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Zhaohui ZhuDepartment of Nuclear Medicine State Key Laboratory of Complex Severe and Rare Diseases Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing China.
Deling LiDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Wang JiaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.
Peng KangDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth hormone-secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed RNA sequencing on human pituitary adenoma stem-like cells (hPASCs) and matched bulk tumors to map a differentiation protein-protein interaction (PPI) network. The function of the C-X-C motif chemokine receptor-4 (CXCR4) gene was tested in hPASCs and the GH3 cell line. The CXCR4-based

Indexed as

68Ga‐PentixaforAMD3465CXCR4growth hormone–secreting pituitary adenomahuman pituitary adenoma stem‐like cellsRNA sequencing

Identifiers

PMID42639247
PMCPMC13501116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.