ArticleInfection and drug resistance2026
Metagenomic Characterization of Nitrite-Negative Urinary Tract Infections and Identification of an
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Urinary tract infections (UTIs) showing negative nitrite results create a diagnostic blind spot for Gram-positive pathogens. The plasmid-mediated resistance genes Methods: Deep metagenomic sequencing was performed on urine samples from 20 patients with complex nitrite-negative UTIs and pyuria in China. Antibiotic resistance genes (ARGs) were profiled using a read-mapping threshold (>50 reads for Results: Discussion: This study provides genomic evidence of high-risk resistance determinants in community nitrite-negative UTIs. However, results are limited by the DNA-level metagenomic approach without culture confirmation. Molecular surveillance is needed to monitor these cryptic multidrug-resistance clusters.
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