ArticleFrontiers in plant science2026
Identification of circRNAs in industrial hemp (
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Circular RNAs (circRNAs) are important regulators of plant development and stress responses, but their roles in 6-benzylaminopurine (6-BA)-induced female flower differentiation in industrial hemp remain unclear. Methods: Industrial hemp plants were treated with 60 mg·L-1 6-BA, and female flower samples were collected at different developmental stages. Genome-wide high-throughput sequencing was used to identify circRNAs. Selected circRNAs and miRNAs were validated by qRT-PCR. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed, and putative circRNA-miRNA-mRNA networks and the protein-coding potential of circRNAs were computationally evaluated. Results: A total of 264 circRNAs were identified. Multiple circRNAs exhibited stage-specific responses to 6-BA. Cs_circ_67024327 showed the strongest induction at the early female flower stage, whereas Cs_circ_44508988 and Cs_circ_21994222 exhibited distinct responses from the early to middle developmental stages. CsSPT5, a flowering-time candidate gene located near the SDR/PAR boundary, was downregulated at the shoot apical meristem stage but upregulated at the early and middle female flower stages. No statistically significant GO terms or KEGG pathways were detected after multiple-testing correction. Computational analyses suggested that several circRNAs may function as miRNA sponges, and some circRNAs contained conserved domains indicating potential protein-coding capacity. Discussion: These findings provide preliminary evidence that 6-BA-responsive circRNAs may participate in female flower differentiation in industrial hemp through predicted ceRNA interactions or mechanisms related to their coding potential. These putative regulatory mechanisms require further experimental validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.