Evidence map›Paper›PMID 42638955›Full record

ArticleFrontiers in immunology2026

B7-H3 (CD276) regulates myeloid-derived suppressor cell differentiation in pulmonary fibrosis.

Francina Gonzalez De Los Santos, Alyssa Rosek, Akira Ando, Sem H Phan, Navin R Mahadevan, Tianju Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francina Gonzalez De Los SantosDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.
Alyssa RosekDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.
Akira AndoDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.
Sem H Phan *Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.
Navin R Mahadevan *Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.
Tianju Liu *Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.

Funding

The role of Tet1 in myofibroblast differentiationR01HL143339 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, TIANJU · 2021 to 2024
$2.5M
BM alterations in exacerbation of pulmonary fibrosisR01HL138417 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PHAN, SEM H · 2018 to 2021
$2.3M
Targeting the immunologic vulnerabilities of small cell lung carcinomaK08CA270077 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Navin Mahadevan · 2022 to 2026
$1.0M
The role of Toll-Like Receptor-9 in type II epithelial cells and fibroblasts during influenza and S. aureus coinfectionF31HL179788 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Francina Elcira Gonzalez De Los Santos · 2026 to 2026
$50k
NCI NIH HHS K08 CA270077NHLBI NIH HHS F31 HL179788NHLBI NIH HHS R01 HL138417NHLBI NIH HHS R01 HL143339
6 · The paper itself

Abstract

Introduction: Myeloid-derived suppressor cells (MDSCs) are elevated in cancer, chronic inflammation and fibrosis. The immune checkpoint molecule B7-H3 (CD276) is upregulated in fibrotic conditions and has been implicated in the expansion and recruitment of MDSCs to the fibrotic lung; however, the underlying mechanism remains unclear. Methods: To investigate the role of B7-H3 in MDSC induction, myeloid differentiation and lung fibrosis, we employed Results: Our results showed that Discussion: Together, these findings reveal that bleomycin-induced B7-H3 signals to the bone marrow, skewing myeloid differentiation toward an immature MDSC phenotype by inhibiting normal myeloid maturation during fibrosis.

Indexed as

B7 AntigensCell DifferentiationMyeloid-Derived Suppressor CellsPulmonary FibrosisAnimalsBleomycinDisease Models, AnimalFibroblastsMiceMice, Inbred C57BLMice, KnockoutB7 AntigensBleomycinCd276 protein, mouseB7-H3fibroblastsfibrosisMDSC (myeloid-derived suppressor cells)myeloid cells

Identifiers

PMID42638955
PMCPMC13500340

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.