ReviewFrontiers in immunology2026
The circadian-microbiome-immune axis in colorectal cancer: mechanisms of spatiotemporal immunosuppression and chronotherapeutic horizons.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Colorectal cancer (CRC) remains a major global oncological challenge, largely because most microsatellite-stable (MSS) tumors exhibit intrinsic resistance to immune checkpoint blockade (ICB). Emerging evidence suggests that the gut microbiome and host circadian rhythm jointly regulate mucosal homeostasis; however, their dynamic integration-defined here as the circadian-microbiome-immune axis-remains incompletely understood in CRC. In this review, we synthesize preclinical findings and the limited available clinical evidence concerning this axis. Experimental studies using genetic and lifestyle-related models of circadian disruption indicate that clock dysfunction may impair the intestinal mucosal barrier and alter microbial composition, including depletion of beneficial taxa such as
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