Evidence map›Paper›PMID 42638904›Full record

ArticleInternational journal of biomaterials2026

The Biocompatibility and Cellular Response of Geristore in Comparison With Different Glass Ionomer Materials on Human Gingival Fibroblast Cells: A Comparative Study on Deep Marginal Elevation.

Mahsa Radafshar, Ardavan Parhizkar

Abstract read
In one paragraph

Article in International journal of biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mahsa RadafsharDepartment of Endodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran 194685-3314, Iran, azad.ac.ir.ORCID https://orcid.org/0000-0002-9491-0632
Ardavan ParhizkarDepartment of Dental Biomaterials, Dental Materials Research Centre, Tehran Medical Sciences Campus, Islamic Azad University, Tehran 194685-3314, Iran, azad.ac.ir.ORCID https://orcid.org/0000-0002-0712-2305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of the current study was to evaluate the biological response(s) of human gingival fibroblast (HGF) cells to Geristore (GS) and compare them with those of conventional glass ionomers (GIs) to determine their impacts on performance and success in deep margin elevation techniques. Methods: Samples of GS, GI Fuji II, and resin-modified glass ionomer (RGI) Fuji II LC were prepared as 6 × 2 mm discs under aseptic conditions and then incubated in 24-well plates. Next, cytotoxicity was investigated using MTT assay after 48 h of exposure with HGFs. In addition, cell morphology was studied via scanning electron microscopy following 48-h incubation. Furthermore, cell adhesion was analyzed using fluorescent staining with phalloidin/4',6-diamidino-2-phenylindole (DAPI). Results: The MTT assay demonstrated that all tested materials exhibited biocompatibility and nontoxicity, with significantly high cell viability after 48 h ( Conclusions: The obtained findings could position GS as a promising candidate for scenarios demanding biological compatibility and reparative capabilities in dental applications, specifically in deep margin elevation.

Indexed as

cell adhesiondeep marginal elevationGeristoregingival fibroblastsglass ionomer

Identifiers

PMID42638904
PMCPMC13501122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.