ArticleFrontiers in medicine2026
Quantitative HBsAg as a biomarker for disease staging in untreated chronic hepatitis B patients: a cross-sectional study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background and aims: Chronic hepatitis B virus (HBV) infection is a major issue in North Africa, where HBeAg-negative profiles are predominant. Distinguishing between chronic infection and active chronic hepatitis using conventional markers is sometimes difficult. Our study assessed the correlation of HBsAg with viral load and liver fibrosis, as well as its performance in distinguishing the different evolving phases of chronic HBV infection. Approach and results: We conducted an analytical cross-sectional study that included 90 HBeAg-negative treatment-naïve patients. All patients underwent biological assessment, HBsAg quantification, viral load, and FibroScan®. Among the 90 patients (mean age: 47.5 ± 11 years; 52.6% women), 65.6% were in the low-replicative chronic infection phase. The median viral load was 328.5 IU/mL, and the median HBsAg level was 213.5 IU/mL. A strong positive correlation was observed between HBsAg and HBV DNA levels ( Conclusion: Quantitative HBsAg measurement is a relevant tool for refining the stratification of untreated HBeAg-negative patients as a complementary surrogate marker. When combined with viral load, transaminases, and FibroScan®, HBsAg could contribute to optimized monitoring and better resource allocation.
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