Evidence map›Paper›PMID 42638866›Full record

ArticleNeurotrauma reports

Differentially Methylated Gene Expression in Professional Fighters with Repetitive Mild Traumatic Brain Injury Is Distinct from Alzheimer's Disease and Associated with Brain Volume.

Grace Weber, Maria Khrestian, Shane Formica, Elizabeth Tuason, Stephen Rao, Jagan Pillai, Aaron Ritter, Charles Bernick, James B Leverenz, Lynn M Bekris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Grace WeberMolecular Pathology and Cytogenomics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Maria KhrestianGenomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Shane FormicaGenomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Elizabeth TuasonGenomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Stephen RaoLou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
Jagan PillaiLou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
Aaron RitterHoag Memorial Hospital Presbyterian, Newport Beach, California, USA.
Charles BernickLou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada, USA.
James B LeverenzDepartment of Neurology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-0896-0749
Lynn M BekrisDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2747-7672

Funding

Immune Mechanisms Underlying the Neuroprotective Effects of Physical Activity in Human and Mouse Models of Genetic Risk for Alzheimers DiseaseR01AG022304 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI LAMB, BRUCE T, RAO, STEPHEN MARK · 2003 to 2021
$13.0M
fMRI as an Imaging Biomarker for Preclinical Alzheimer's DiseaseR56AG022304 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI RAO, STEPHEN MARK · 2009 to 2009
$411k
NIA NIH HHS R01 AG022304NIA NIH HHS R56 AG022304
6 · The paper itself

Abstract

Repetitive mild traumatic brain injury (RMTBI) and Alzheimer's disease (AD) share some pathological features, such as tau pathology, inflammation, and neurodegeneration. Tissue injury and aging are linked to cellular DNA methylation alterations in the circulation, which can result in altered gene expression, making it a promising therapeutic target for dysfunctional gene expression. It is unknown whether DNA methylation and potentially related gene expression pathophysiological mechanisms are shared between athletes exposed to RMTBI and AD. The aim was to explore the blood DNA methylomes and transcriptomes from a cohort of professional fighters (PFs) with RMTBI and AD to understand if there are significant differences in the DNA methylome that could potentially impact the transcriptome and thus contribute to pathophysiology in RMTBI. Given that RMTBI and AD share pathological features, it was hypothesized that RMTBI could also share DNA methylome and transcriptome features with AD. The methylomes (Infinium Human Methylation EPIC BeadChip) and transcriptomes (Illumina NovaSeq 6000) from active PFs (aPFs) or retired PFs (rPFs) were compared with AD and cognitively normal (CN) control groups. Several differentially methylated positions (DMPs) in the genome were linked to differentially expressed RNA transcripts that were unique to group comparison. Of these,

Indexed as

Alzheimer’s diseaseDNA methylationrepetitive head trauma

Identifiers

PMID42638866
PMCPMC13500973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.