Evidence map›Paper›PMID 42638860›Full record

ArticleInternational journal of ophthalmology2026

Abnormalities in retinal vascularity and blood perfusion associated with early syphilis revealed by optical coherence tomography angiography.

Xiao-Liu Wang, Yan-Qiong Zhu, Hui-Yin Zheng, Xin-Yi Luo, Jie-Hui Li, Hou-Jian Zhang, Zu-Guo Liu, Qiu-Ping Liu

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Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xiao-Liu WangDepartment of Dermatology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Yan-Qiong ZhuDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Hui-Yin ZhengDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Xin-Yi LuoDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Jie-Hui LiDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Hou-Jian ZhangDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Zu-Guo LiuDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Qiu-Ping LiuDepartment of Ophthalmology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore the feasibility of optical coherence tomography angiography (OCTA) in the early detection of syphilis and syphilitic chorioretinopathy.

methodsPatients with newly diagnosed syphilis were enrolled from September 2022 to November 2023. All the participants underwent serological examinations including rapid plasma reagin (RPR) test and treponema pallidum particle agglutination (TPPA) test, as well as macular OCTA scanning. Quantitative indicators including macular vessel flow density (VFD), vessel length density (VLD), and foveal avascular zone (FAZ) were measured and analyzed.

resultsA total of 44 participants were recruited in this study, including 24 patients in the syphilis group (14 males, mean age: 30.83±9.59y) and 20 healthy individuals in the control group (6 males, mean age: 29.6±11.86y). Compared with the control group, the syphilis group presented significantly higher macular VLD and VFD (

conclusionSyphilis patients with either low or high RPR titers show increased macular VLD and VFD in the absence of obvious visual impairment, indicating the potential of OCTA microvascular parameters for early auxiliary diagnosis of syphilitic ocular lesions.

Indexed as

microvascular morphologyoptical coherence tomography angiographysyphilis

Identifiers

PMID42638860
PMCPMC13501026

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