Evidence map›Paper›PMID 42638815›Full record

ReviewDigital health

Ethical governance of artificial intelligence in digital health for Indigenous populations: A narrative review and conceptual framework.

Amal Khan, Alyson S N Bear, Mairyn Rackow, Cassandra Opikokew Wajuntah, Kenneth Lai, Veronica McKinney, John Costa, Ivar Mendez

Abstract readReview
In one paragraph

Review in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amal KhanDepartment of Community Health & Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.ORCID https://orcid.org/0000-0001-8615-4024
Alyson S N BearVirtual Health Hub, Saskatoon, SK, Canada.
Mairyn RackowCollege of Law, University of Saskatchewan, Saskatoon, SK, Canada.
Cassandra Opikokew WajuntahDepartment of Community Health & Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Kenneth LaiSaskatchewan Environments for Indigenous Health Research (SK-NEIHR), University of Saskatchewan, Saskatoon, SK, Canada.
Veronica McKinneyVirtual Health Hub, Saskatoon, SK, Canada.
John CostaVirtual Health Hub, Saskatoon, SK, Canada.
Ivar MendezVirtual Health Hub, Saskatoon, SK, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) integration into digital health care delivery is rapidly expanding and is increasingly viewed as a promising approach for improving access to care, strengthening diagnostic decision-making, and addressing persistent health inequities experienced by Indigenous populations. Although AI-enabled digital health applications offer potential benefits such as scalability, personalization, and improved clinical decision support, they also raise critical ethical concerns related to equitable implementation, culturally grounded design, representative data usage accountability, privacy protection, and Indigenous data sovereignty. A coherent ethical governance framework is necessary to guide the responsible development, deployment, and evaluation of AI applications implemented in digital health solutions involving Indigenous communities. A narrative review was conducted to critically assess recent literature (2020-2025) addressing ethical considerations in the integration of AI into digital health care delivery for Indigenous populations. Searches were performed in MEDLINE, PubMed, Web of Science, and Scopus using terms related to artificial intelligence, digital health, Indigenous populations, and ethics, with supplementary grey literature searches conducted to identify policy and implementation reports. Studies were selected based on relevance to AI-enabled digital health initiatives implemented in digital health contexts involving Indigenous communities in Canada, the United States, Australia, New Zealand, and the United Kingdom, and were synthesized using thematic narrative analysis. Six themes denoting ethical domains were identified: (1) co-design of AI technologies, (2) culturally grounded implementation, (3) bias and representative data, (4) accountability, transparency, and intelligibility, (5) privacy and Indigenous data sovereignty, and (6) resource accessibility. These domains function as interconnected components of ethical governance, with participatory governance and Indigenous data sovereignty emerging as foundational cross-cutting principles. The proposed framework is not intended as a pan-Indigenous or one-size-fits-all model. Instead, it is conceptualized as a flexible, distinctions-based ethical governance framework that must be adapted to the specific cultural, geographic, and governance contexts of individual Indigenous communities. Based on this analysis, we propose a conceptual ethical governance framework to support policymakers, clinicians, health systems, digital health developers, as well as Indigenous communities in identifying ethically appropriate safeguards across the lifecycle of AI-enabled digital health initiatives planned or implemented in Indigenous communities.

Indexed as

AI ethicsartificial intelligencedigital healthethical frameworkhealth equityindigenous data sovereigntyindigenous health

Identifiers

PMID42638815
PMCPMC13500953

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.