Evidence map›Paper›PMID 42638806›Full record

ArticleFrontiers in tuberculosis2026

Sigma factor M induces an ESX-4-focused regulon in

Jill G Canestrari, Shawn Gianola, Keith M Derbyshire, Todd A Gray

Abstract read
In one paragraph

Article in Frontiers in tuberculosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jill G Canestrari *Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, United States.
Shawn Gianola *Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, United States.
Keith M DerbyshireDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, United States.
Todd A GrayDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, United States.

Funding

Characterization of a novel kin recognition system in mycobacteriaR01AI181948 · NIAID · WADSWORTH CENTER · PI Todd Gray · 2024 to 2026
$1.4M
Dissecting and connecting the SigM stimulus and ESX-4 secretory response in mycobacteriaR01GM144372 · NIGMS · WADSWORTH CENTER · PI DERBYSHIRE, KEITH M, GRAY, TODD · 2022 to 2023
$771k
Contact-dependent transcriptional networks in mycobacterial speciesR21AI135173 · NIAID · WADSWORTH CENTER · PI CHAMPION, MATTHEW M, DERBYSHIRE, KEITH M · 2018 to 2019
$463k
NIAID NIH HHS R01 AI181948NIAID NIH HHS R21 AI135173NIGMS NIH HHS R01 GM144372
6 · The paper itself

Abstract

Mycobacteria encode as many as five distinct Type VII (ESX) secretion systems that function in nutrient acquisition, cell-cell interaction, membrane integrity and pathogenesis. The biological activities of ESX systems are determined by the effector proteins they secrete. ESX-4 is the ancestral secretion system and is conserved throughout mycobacteria, including

Indexed as

DUF3558ESX-4non-tuberculous mycobacteriaSigMtype VII secretion system

Identifiers

PMID42638806
PMCPMC13491425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.