Evidence map›Paper›PMID 42638776›Full record

ArticleFrontiers in immunology2026

Decidua macrophages display a restrained inflammatory profile during chorioamnionitis.

Neema Pithia, Carmelo V Musumarra, Giulia Protti, Giorgia Del Vecchio, Fei-Man Hsu, Feiyang Ma, Monica Cappelletti, Tamara Tilburgs, Nina S Prasanphanich, Lisa A Miller and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Neema Pithia *Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Carmelo V Musumarra *Department of Chemistry, Life Sciences and Environmental Sustainability (S.C.V.S.A.), University of Parma, Parma, Italy.
Giulia ProttiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Giorgia Del VecchioInstitute for Quantitative and Computational Biosciences-Collaboratory, University of California, Los Angeles, Los Angeles, United States.
Fei-Man HsuInstitute for Quantitative and Computational Biosciences-Collaboratory, University of California, Los Angeles, Los Angeles, United States.
Feiyang MaInstitute for Quantitative and Computational Biosciences-Collaboratory, University of California, Los Angeles, Los Angeles, United States.
Monica CappellettiDepartment of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, Los Angeles, CA, United States.
Tamara TilburgsDivision of Immunobiology, Cincinnati Children's Hospital Research Foundation, The University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Nina S PrasanphanichDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Lisa A MillerCalifornia National Primate Research Center, University of California, Davis, Davis, United States.
Marco MorselliDepartment of Chemistry, Life Sciences and Environmental Sustainability (S.C.V.S.A.), University of Parma, Parma, Italy.
Matteo PellegriniInstitute for Quantitative and Computational Biosciences-Collaboratory, University of California, Los Angeles, Los Angeles, United States.
Alan H JobeDivision of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Research Foundation, and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Claire A ChougnetDivision of Immunobiology, Cincinnati Children's Hospital Research Foundation, The University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Pietro Presicce *Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Suhas G Kallapur *Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.

Funding

Transcriptomics and biomarkers of fetal neuroinflammationR01HD098389 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALLAPUR, SUHAS · 2019 to 2023
$3.8M
Training in Developmental HematologyT32HL086345 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2007 to 2022
$3.8M
Training CoreTL1DK132768 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2021 to 2026
$3.4M
Network CoreU2CDK129496 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEX BUI · 2021 to 2026
$2.9M
Prenatal inflammatory exposures and neonatal immune developmentU01ES029234 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A. · 2017 to 2021
$2.7M
Drug repurposing of a novel synthetic progestin for the prevention of preterm labor and fetal inflammationR01HD114495 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUHAS KALLAPUR, Sam Antonio MESIANO · 2024 to 2026
$2.0M
UCLA Pediatric Research Education Program in Bioinformatics, Computational Biology, and OmicsR25HD109116 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sherin U Devaskar, JOSEPHINE M ENCISO · 2023 to 2026
$645k
NHLBI NIH HHS T32 HL086345NICHD NIH HHS R01 HD098389NICHD NIH HHS R01 HD114495NICHD NIH HHS R25 HD109116NIDDK NIH HHS TL1 DK132768NIDDK NIH HHS U2C DK129496NIEHS NIH HHS U01 ES029234
6 · The paper itself

Abstract

Introduction: Decidual macrophages (DMs) are strategically located at the maternal-fetal interface to orchestrate innate host defense while balancing tolerance to the allogenic fetus. An important pregnancy complication is chorioamnionitis characterized by infection/inflammation in the fetal membranes and the amniotic fluid with upregulation of TNFα and other pro-inflammatory cytokines. The goal of this study was to determine maternal vs fetal origin of DMs and to investigate whether TNF signaling play a role in DM response to chorioamnionitis. Methods: Decidua tissue from pregnant Rhesus macaques given intraamniotic injection of lipopolysaccharide/saline with or without the TNF inhibitor Adalimumab (n=33) and human subjects with/out chorioamnionitis (n=11) were used for bulk RNAseq, scRNAseq, and flow cytometry experiments. Results: In both human and Rhesus macaques, DMs coordinately upregulate both pro- and anti-inflammatory cytokines during chorioamnionitis. Although DMs did not express TNF during chorioamnionitis, inhibition of TNF signaling downregulated 50% of LPS induced genes. About 4% of the DMs were of male fetus origin. These fetal origin DMs selectively upregulated Discussion: We suggest that DMs orchestrate a carefully balanced host defense with a restrained pro-inflammatory profile during chorioamnionitis to potentially prevent adverse outcomes while protecting the mother-fetus dyad. Activation of fetal origin macrophages during chorioamnionitis may have implications for shaping neonatal immune responses.

Indexed as

ChorioamnionitisDeciduaMacrophagesAnimalsCytokinesFemaleHumansInflammationLipopolysaccharidesMacaca mulattaMalePregnancySignal TransductionTumor Necrosis Factor-alphaCytokinesLipopolysaccharidesTumor Necrosis Factor-alphachorioamnionitisinflammationinnate immunitymacrophagesreproductive immunology

Identifiers

PMID42638776
PMCPMC13500772

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.