ArticleFrontiers in endocrinology2026
Association between thyroid feedback quartile index and FIB-4-defined fibrosis risk in patients with metabolic dysfunction-associated steatotic liver disease, type 2 diabetes mellitus, and treated primary hypothyroidism: an exploratory cross-sectional study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) frequently coexists with Type 2 Diabetes Mellitus (T2DM) and Primary Hypothyroidism (PH); nevertheless, the relationship between thyroid hormone sensitivity and FIB-4-defined fibrosis risk across these metabolic diseases is yet unknown. Methods: In 102 patients with MASLD, MASLD+T2DM, and MASLD+T2DM+treated PH (34 per group), this exploratory cross-sectional study examined the association between the Thyroid Feedback Quantile Index (TFQI) and the Fibrosis-4 Index (FIB-4). The cumulative distribution functions of TSH and FT4 were used to calculate TFQI. A surrogate indicator of the risk of fibrosis was FIB-4. G*Power 3.1.9.7 was used for Results: In the MASLD-alone group, TFQI and FIB-4 had a significant inverse correlation in unadjusted analysis ( Conclusions: Age played a major role in explaining the inverse correlation between TFQI and FIB-4 in patients with MASLD alone in this exploratory study. These results should be considered hypothesis-generating and should be validated in bigger prospective trials with direct measurements of fibrosis. Future research may benefit from the heterogeneous associations across metabolic backgrounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.