Evidence map›Paper›PMID 42638633›Full record

ArticleFrontiers in tuberculosis2025

Proteomic insights into mycobacterial responses to elevated riboflavin reveal a role for flavin-sequestering proteins in flavin homeostasis.

Nurudeen Oketade, Karen M Dobos

Abstract read
In one paragraph

Article in Frontiers in tuberculosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nurudeen OketadeDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.
Karen M DobosDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Funding

Research Resources and Workforce Development for the Rocky Mountain Regional Biocontainment Laboratory at Colorado State UniversityUC7AI180308 · NIAID · COLORADO STATE UNIVERSITY · PI Raymond Paul Goodrich · 2023 to 2026
$13.5M
T cell recognition of the MR1 presented microbial metabolomeR01AI147954 · NIAID · UNIVERSITY OF CHICAGO · PI ADAMS, ERIN JUNE, HILDEBRAND, WILLIAM · 2019 to 2023
$7.3M
NIAID NIH HHS R01 AI147954NIAID NIH HHS UC7 AI180308
6 · The paper itself

Abstract

Riboflavin biosynthesis is essential for most microorganisms, yet its production is tightly regulated due to the potential toxic effect of riboflavin and its derivatives. While regulatory mechanisms for this process have been described in other organisms, none has been identified in mycobacteria. Uncovering such a mechanism will be critical to fully exploit the riboflavin biosynthetic pathway as a pharmacological target. We previously observed that

Indexed as

flavin sequestershomeostasisisoniazidmycobacteriaproteomicsriboflavinstress responsetuberculosis

Identifiers

PMID42638633
PMCPMC13494985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.