Evidence map›Paper›PMID 42638417›Full record

ArticleJournal of microbiology and biotechnology2026

The Bacterial Metabolite Lndole-3-Propionic Acid Alleviates Acetaminophen-Induced Acute Liver Injury Partly through the Aryl Hydrocarbon Receptor Pathway.

Bo Zhou, Xiushang Ye, Yuan Tian, Xintong Wang, Xiaozhang Xu, Yi Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bo ZhouDepartment of General Surgery, Ningbo Medical Center Li HuiLi Hospital (The Affiliated Lihuili Hospital of Ningbo University), 315040, Ningbo, Zhejiang, P. R. China.
Xiushang YeDepartment of General Surgery, Ninghai Chengguan Hospital (Ninghai Branch of Li Huili Hospital), 315000, Ningbo, Zhejiang, P. R. China.
Yuan TianDepartment of General Surgery, Ningbo Medical Center Li HuiLi Hospital (The Affiliated Lihuili Hospital of Ningbo University), 315040, Ningbo, Zhejiang, P. R. China.
Xintong WangDepartment of Breast and Thyroid Surgery, The Huaian Clinical College of Xuzhou Medical University, Huai'an, 223300, Huaian, Jiangsu, P. R. China.
Xiaozhang XuDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, 223300, Huaian, Jiangsu, P. R. China.
Yi RenDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, 223300, Huaian, Jiangsu, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP)-induced liver injury is a major cause of acute liver injury (ALI). Indole-3-propionic acid (IPA), a gut microbiota-derived tryptophan metabolite with potent anti-inflammatory and antioxidant properties, has not been fully explored for its therapeutic potential in APAP-induced ALI. APAP-induced liver injury is often accompanied by dysregulation of both the gut microbiota and the intrahepatic immune system. In our study, IPA levels were markedly reduced in the ALI model, reflecting impaired gut tryptophan metabolism.

Indexed as

AcetaminophenBacteriaChemical and Drug Induced Liver InjuryIndolesPropionatesReceptors, Aryl HydrocarbonAnimalsApoptosisBasic Helix-Loop-Helix ProteinsDisease Models, AnimalHepatocytesHumansLiverMaleMiceMice, Inbred C57BL3-(indol-3-yl)propionic acidAcetaminophenBasic Helix-Loop-Helix ProteinsIndolesPropionatesReceptors, Aryl HydrocarbonAcetaminophenAcute liver injuryAryl hydrocarbon receptorsIndole-3-propionic Acid

Identifiers

PMID42638417
PMCPMC13506254

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.