Evidence map›Paper›PMID 42638140›Full record

ArticleJournal of animal science and biotechnology2026

Mannooligosaccharides modulate mucin O-glycan-gut microbe interactions and preserve the intestinal barrier in weaned piglets.

Shanghang Liu, Nian Liu, Yutao Qiu, Hao Li, Fan Zhang, Qian Jiang, Jing Wang, Yulong Yin, Bie Tan, Xiaokang Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shanghang Liu *College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Nian Liu *College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Yutao QiuCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Hao LiCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Fan ZhangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Qian JiangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Jing WangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Yulong YinInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Bie TanCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. bietan@hunau.edu.cn.
Xiaokang MaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. maxiaokang@hunau.edu.cn.

Funding

Hunan Provincial Natural Science Foundation of China 2026JJ50411Scientific Research Fund of Hunan Provincial Education Department 25A0213
6 · The paper itself

Abstract

backgroundThe intestinal microbiota and mucosal barrier are closely intertwined, with mucin O-glycans playing a key role in maintaining intestinal homeostasis. However, how nutrition regulates mucin O-glycans remains poorly understood. This study investigated the regulatory effects of mannooligosaccharides (MOS) on mucin secretion and O-glycan modification in a weaned piglet model. We evaluated the effects of MOS on intestinal morphology, gut microbiota, mucin secretion, and O-glycosylation profiles in weaned piglets.

resultsTranscriptome analysis revealed that MOS influenced key KEGG pathways, including mucin O-glycan biosynthesis, through the regulation of genes such as GALNT, GCNT3, and POFUT1. Furthermore, MOS increased the proportion of Core 2 structures in mucin and modulated the proportion of long-chain, sulfated and sialylated O-glycans, which may help protect the mucus layer from microbial degradation. Moreover, MOS improved colonic microbiota composition by promoting beneficial Lactobacillus species and suppressing potentially pathogenic Escherichia coli.

conclusionThis study highlights the molecular effects of MOS on mucin synthesis and modification, which may help preserve intestinal microbiota balance. These effects are important for maintaining intestinal barrier function in weaned piglets.

Indexed as

GlycosylationIntestinal damageIntestinal microbiotaMannooligosaccharidesO-glycansWeaned piglets

Identifiers

PMID42638140
PMCPMC13501716

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.