ArticleClinical rheumatology2026
Prevalence and transient impact of childhood abuse and neglect on health-related quality of life in Mexican patients with early rheumatoid arthritis.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAdverse childhood experiences are risk factors for rheumatic diseases outcomes. Prospective studies from low- and middle-income countries remain limited. This study aimed to estimate the prevalence of childhood abuse and neglect (CAN) in Mexican patients with recent-onset rheumatoid arthritis (RA) and to evaluate its impact on outcomes during the first year of follow-up. PATIENTS AND
methodsThis nested cross-sectional study was conducted within an ongoing prospective cohort initiated in 2004, with data collected from June to December 2025. Clinical, laboratory, and patient-reported outcomes were collected throughout patient follow-up. In 2025, CAN was introduced as a key outcome, assessed and defined by self-report and using a locally developed and validated 29-item scale encompassing six dimensions. Raw scores for each of the eight SF-36 domains were determined. The area under the curve was calculated for each cumulative outcome. Adjusted linear regression models were used to evaluate the association between CAN and outcomes scores.
resultsAmong 156 patients, 41 (26.3%) met criteria for CAN. CAN was significantly associated with lower scores in the physical functioning, role-physical, social functioning, and pain domains of the SF-36. CAN did not have a significant impact on other baseline outcomes. High baseline disease activity impacted all the SF-36 domains. The impact of CAN on cumulative SF-36 domain scores was no longer observed early during follow-up.
conclusionsCAN was reported by one in four Mexican patients in an early RA cohort, and was associated with a significant, albeit temporary, reduction in some dimensions of health-related quality of life. Keypoints • Childhood abuse or neglect was reported by 26.3% of patients with recent-onset rheumatoid arthritis. • Childhood abuse or neglect and high baseline disease activity were associated with poorer first-year health-related quality of life. • The negative impact of childhood abuse or neglect on health-related quality of life was no longer evident after 2 months of early treatment.
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