Evidence map›Paper›PMID 42637924›Full record

ArticleNature neuroscience2026

Lack of sensorimotor toxicity when using the clinical SMN expression cassette in scAAV9.

Maria H H Balch, Anton J Blatnik, Kaitlyn M Kray, Vicki L McGovern, Summer R Baxley, Kristen Kent, Rochelle Rodrigo, Arthur H M Burghes, W David Arnold

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria H H Balch *Department of Neurology, Neuromuscular Division, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-2011-6345
Anton J Blatnik *Department of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kaitlyn M KrayDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Vicki L McGovernDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-3979-9596
Summer R BaxleyDepartment of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kristen KentDepartment of Neurology, Neuromuscular Division, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Rochelle RodrigoDepartment of Neurology, Neuromuscular Division, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Arthur H M BurghesDepartment of Neurology, Neuromuscular Division, The Ohio State University Wexner Medical Center, Columbus, OH, USA. burghes.1@osu.edu.ORCID http://orcid.org/0000-0001-9031-1555
W David ArnoldDepartment of Neurology, Neuromuscular Division, The Ohio State University Wexner Medical Center, Columbus, OH, USA. wdavidarnold@health.missouri.edu.ORCID http://orcid.org/0000-0001-9889-7036

Funding

Therapy for Spinal Muscular AtrophyR01HD060586 · NICHD · OHIO STATE UNIVERSITY · PI BURGHES, ARTHUR H. M. · 2010 to 2021
$3.7M
Genetic Suppression of SMN Mutations in Spinal Muscular AtrophyR01NS123736 · NINDS · OHIO STATE UNIVERSITY · PI BURGHES, ARTHUR H. M. · 2021 to 2025
$2.5M
The Role of SMN in Aging Related Weakness: A Novel Therapeutic TargetR56AG055795 · NIA · OHIO STATE UNIVERSITY · PI ARNOLD, WILLIAM DAVID · 2019 to 2019
$504k
Maladaptive Remodeling of the Neuromuscular Synapse Following Central Nervous System InjuryF32NS126298 · NINDS · OHIO STATE UNIVERSITY · PI BALCH, MARIA HELEN HARLEY · 2023 to 2025
$187k
AAPM&R | Foundation for Physical Medicine and Rehabilitation (Foundation for PM&R) Rehabilitation Research Experience for Medical StudentsU.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD060586U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F32NS126298U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS123736U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R56AG055795
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.