In one paragraphArticle in Npj viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Benjamin GutjahrInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0009-0000-6982-8592 L Mathias MichaelyDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-6271-5253 Caroline BostInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-6523-2054 Balal SadeghiInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-6394-4170 Filipe TomazInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0002-0375-4698 Markus KellerInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0003-3229-8377 Sven ReicheDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-7575-2483 Sandra DiederichInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-6740-3312 Mathias StreitzDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-7534-5693 Anne Balkema-BuschmannInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0001-7613-9592 Martin H GroschupInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0000-0003-0215-185X Kerstin FischerInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany. Kerstin.Fischer@fli.de.ORCID http://orcid.org/0000-0002-8707-3442 Funding
Agricultural Research Service Development of Agriculture Model Capabilities for Emerging Disease Threats" NACA #58-3022-3-004European Commission CCHFVaccineHORIZON EUROPE Framework Programme CCHFVACIM #101137033
6 · The paper itselfAbstract
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne orthonairovirus widely distributed across Asia, Africa, the Middle East, and Southern Europe, causing severe illness and hemorrhagic fever in humans. While sheep usually show no clinical symptoms, they develop viremia and can play a key role in transmitting the virus to ticks and humans. Despite their importance in transmission, our understanding of infection dynamics in these animals remains limited. To bridge this knowledge gap, we conducted a controlled study in which six Pomeranian Coarsewool sheep were experimentally infected with CCHFV, strain Kosovo Hoti, and monitored over 21 days. All sheep developed transient fever and viremia. Necropsies at 5-7 days post infection (dpi) revealed highest viral loads in liver, spleen, testicles, and lymphoid tissues. Seroconversion occurred by 7 dpi and virus-neutralizing antibodies were detectable by day 8. These findings enhance our understanding of CCHFV infection dynamics in sheep and will aid future research, including vaccine development.
Identifiers
PMID42637838
PMCPMC13503663
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