Evidence map›Paper›PMID 42637832›Full record

ArticleCardiovascular and interventional radiology2026

A Prospective, Randomized Controlled Trial of Intravascular Ultrasound-Guided versus Digital Subtraction Angiography-Guided Mechanical Thrombectomy in Acute Intermediate-Risk and High-Risk Pulmonary Embolism.

Da Li, Xiaosong Zhang, Yusheng Wang, Hao Tang, He Huang, Xiaomin Huang, Hongyu Shi, Bin Xu, Honggang Zhang

Abstract read
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In one paragraph

Article in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Da LiDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China.
Xiaosong ZhangDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China.
Yusheng WangDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China.
Hao TangDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China.
He HuangDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China.
Xiaomin HuangDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China.
Hongyu ShiDepartment of Cardiology, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, China.
Bin XuDepartment of Cardiology, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, China.
Honggang ZhangDepartment of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, NO.6 East Zhenhua Road, Lianyungang, 222006, China. zhanghongganglyg@yeah.net.

Funding

Baoshan District Health Commission Talents BSWSYX-20242China Academy of Information and Communications Technology 2023-325Shanghai Shen Kang Hospital Development Center SHDC2023CRD026
6 · The paper itself

Abstract

purposeThis study aimed to compare the efficacy and safety of intravascular ultrasound (IVUS)-guided mechanical thrombectomy with those of conventional digital subtraction angiography (DSA)-guided mechanical thrombectomy in patients with intermediate- to high-risk acute pulmonary embolism. MATERIALS AND

methodsThis is a prospective, 1:1 block-randomized, controlled, open-label, blinded-endpoint (PROBE design), multi-center, superiority trial (Protocol Version 1.0, dated February 1, 2025). Eligible patients aged 18-75 years, diagnosed with intermediate-high-risk acute pulmonary embolism, with right ventricular/left ventricular diameter ratio (RV/LV) ≥ 0.9 on computed tomography pulmonary angiography (CTPA) will be included. The exclusion criteria included unsuitable vascular anatomy for the thrombectomy device; chronic pulmonary hypertension; left bundle branch block; chronic left heart failure (LVEF ≤ 30%); renal dysfunction (serum creatinine > 1.8 mg/dL or > 159 μmol/L); coagulopathy; contrast media hypersensitivity. The intervention group will undergo IVUS-guided mechanical thrombectomy using the Tendvia System (Shanghai Tendvia Medical Devices Co., Ltd.) under the guidance of a Philips IVUS system. The control group will undergo conventional DSA-guided mechanical thrombectomy using the same Tendvia System. The primary efficacy endpoint is the reduction in the RV/LV ratio from baseline to 48 h post-procedure. The primary safety endpoint is a composite of major adverse events (MAEs) within 48 h, including procedure-related mortality, major bleeding, and clinical deterioration requiring escalation of care.

Indexed as

Digital subtraction angiographyIntermediate-risk and high-risk pulmonary embolismIntravascular ultrasoundMechanical thrombectomyPulmonary embolismRandomized controlled trialRight ventricular functionThrombectomy guidance

Identifiers

PMID42637832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.