Evidence map›Paper›PMID 42637755›Full record

ArticleNature communications2026

Cryo-EM insights into isoform-specific properties of the IP

Mariah R Baker, Xiaoxuan Lin, Guizhen Fan, Ariel Martinez-Chavez, Larry E Wagner, Sundeep Malik, Tyler Allison, Briar Bell, Alexander B Seryshev, Julio Cordero-Morales and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mariah R Baker *Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1613-9387
Xiaoxuan Lin *Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-1920-5482
Guizhen Fan *Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6741-6989
Ariel Martinez-ChavezDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Larry E WagnerDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA.
Sundeep MalikDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA.
Tyler AllisonMD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0009-0003-9513-8554
Briar BellDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9797-6402
Alexander B SeryshevDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Julio Cordero-MoralesDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6505-5403
Matthew L BakerDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
David I YuleDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA. david_yule@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-6743-0668
Irina I SeryshevaDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. irina.i.serysheva@uth.tmc.edu.ORCID http://orcid.org/0000-0001-6266-3422

Funding

ACQUISITION OF HIGH-THROUGHPUT 200 kV CRYO-TEMS10OD032204 · OD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2022 to 2022
$2.0M
Mechanisms of inositol trisphosphate receptor-mediated calcium signalingR35GM153178 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Irina I Serysheva · 2024 to 2026
$1.7M
Defining architecture of EC coupling machinery in situR21AR082833 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2023 to 2024
$372k
NIAMS NIH HHS R21 AR082833NIGMS NIH HHS R35 GM153178NIH HHS S10 OD032204U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R21AR082833U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM153178U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM153178-01S1U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) S10OD032204
6 · The paper itself

Abstract

Calcium release through inositol 1,4,5-trisphosphate receptors (IP

Indexed as

Cryoelectron MicroscopyInositol 1,4,5-Trisphosphate ReceptorsAdenosine TriphosphateAnimalsBinding SitesCalciumHumansInositol 1,4,5-TrisphosphateModels, MolecularProtein ConformationProtein IsoformsAdenosine TriphosphateCalciumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsProtein Isoforms

Identifiers

PMID42637755
PMCPMC13503717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.