Evidence map›Paper›PMID 42637749›Full record

ArticleNature communications2026

Spinal nociceptive denervation impedes subsequent chronic autonomic remodeling after myocardial infarction in male swine.

Valerie Y H van Weperen, Jonathan D Hoang, Neil R Jani, Shail Avasthi, Christopher A Chan, Kuan Cao, Zulfiqar A Lokhandwala, Maryam Emamimeybodi, Karim Atmani, Marmar Vaseghi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Valerie Y H van Weperen *UCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0672-9463
Jonathan D Hoang *UCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3762-9596
Neil R JaniUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Shail AvasthiUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4776-7781
Christopher A ChanUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Kuan CaoUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Zulfiqar A LokhandwalaUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5000-4611
Maryam EmamimeybodiUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6858-3885
Karim AtmaniUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3584-0694
Marmar VaseghiUCLA Electrophysiology Programs, Division of Cardiology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA. mvaseghi@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-9701-9706

Funding

Ventricular arrhythmias and mechanisms of parasympathetic dysfunction following myocardial infarctionR01HL148190 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VASEGHI, MARMAR · 2020 to 2024
$3.2M
NHLBI NIH HHS R01 HL148190U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148190U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL70626
6 · The paper itself

Abstract

After chronic myocardial infarction (MI), pathological autonomic remodeling, including vagal dysfunction and sympathoexcitation, predisposes to ventricular arrhythmias (VT/VF). However, what underlies this functional and structural remodeling remains unknown. We hypothesized that spinal nociceptive afferent signaling initiates and perpetuates these pathological autonomic changes. We employed cervicothoracic epidural resiniferatoxin (RTX) to ablate spinal nociceptive neurons in male pigs before MI, and assessed autonomic and electrophysiological function four-to-six weeks post-infarction. Compared to vehicle-treated infarcted animals, epidural RTX attenuated the loss of vagal tone and baroreflex sensitivity, reduced spinal cord inflammation, glial activation, and circulating stress and inflammatory markers, and stabilized electrophysiological parameters, lowering VT/VF inducibility. In a separate cohort, acute C7-T1 nociceptive afferent ablation after chronic MI acutely restored vagal function and decreased VT/VF inducibility. This study demonstrates that cervicothoracic spinal nociceptive afferents significantly contribute to MI-induced autonomic remodeling and VT/VF, providing novel insight into the mechanisms underlying sympathovagal imbalance after MI.

Indexed as

Autonomic Nervous SystemMyocardial InfarctionNociceptorsSpinal CordAnimalsBaroreflexDiterpenesMaleSwineVagus NerveDiterpenesresiniferatoxin

Identifiers

PMID42637749
PMCPMC13503775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.