Evidence map›Paper›PMID 42637719›Full record

ArticleNature communications2026

Dysregulated differentiation kinetics underlie the essential role of DNA damage repair in placental development.

Shanshan Yi, Mingzhu Wang, Qianshu Zhu, Yanxin Huang, Jing Xiao, Ming Zong, Wenju Liu, Xingyi Zhou, Jincan He, Mian Wang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shanshan YiShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Mingzhu WangShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Qianshu ZhuChongqing Key Laboratory of Human Embryo Engineering and Precision Medicine, NHC Key Laboratory of Birth Defects and Reproductive Health, Center for Reproductive Medicine, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Yanxin HuangShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Jing XiaoShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Ming ZongShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Wenju LiuShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xingyi ZhouShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Jincan HeShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Mian WangShanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Kexin HeShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xiaochen KouShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Yanhong ZhaoShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Hong WangShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Rui GaoShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. gaorui@tongji.edu.cn.ORCID http://orcid.org/0000-0002-0916-0436
Shaorong GaoShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. gaoshaorong@tongji.edu.cn.ORCID http://orcid.org/0000-0003-1041-3928
Guang YangShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. gyangbio@stanford.edu.ORCID http://orcid.org/0000-0002-1910-9271
Jiayu ChenShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. chenjiayu@tongji.edu.cn.ORCID http://orcid.org/0000-0003-4755-8901
Cizhong JiangShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. czjiang@tongji.edu.cn.ORCID http://orcid.org/0000-0001-5406-2360

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32330030
6 · The paper itself

Abstract

The placenta orchestrates maternal-fetal exchanges, and its dysfunction compromises pregnancy outcomes. Somatic cell nuclear transfer (SCNT) placentas offer a model to investigate such dysfunction. However, SCNT placentas exhibit severe pathological features that remain poorly understood. Using single-nucleus multi-omics profiling, we uncover defective differentiation programs in SCNT placentas, including the persistent multipotency of arrested trophoblast precursors and an aberrant differentiation trajectory in the junctional zone. In addition, SCNT placentas demonstrate impaired VEGF signaling, which subsequently compromises labyrinthine vascularization. Mechanistically, we identify reprogramming-induced DNA damage as a core driver of these defects. Furthermore, we trace this genomic instability to the loss of donor cell-inherited H3K27me3 protection, an epigenetic deficiency that correlates with specific DNA damage-associated regions. Consistently, enhancing DNA damage repair pathways restores proper trophoblast differentiation kinetics and vascular transport capacity. Collectively, our study reveals that genomic instability acts as a barrier to placental development, providing a molecular framework to understand compromised placental function.

Indexed as

Cell DifferentiationDNA DamageDNA RepairPlacentaPlacentationAnimalsFemaleGenomic InstabilityHistonesHumansKineticsMiceNuclear Transfer TechniquesPregnancySignal TransductionTrophoblastsHistonesVascular Endothelial Growth Factor A

Identifiers

PMID42637719
PMCPMC13503693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.