ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
Homeostatic Coupling of Cortical and Brainstem Delta Rhythms in Sleeping Infant Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The emergence of the cortical delta rhythm (1-4 Hz) during quiet sleep (QS) is a major milestone in brain development. In rats, this milestone is achieved between 8 and 12 d of postnatal (P) age. We previously reported an age-dependent increase in delta-rhythmic activity in the medullary parafacial zone (PZ) that is synchronized with cortical delta and entrained by breathing. Here, we ask whether this long-distance synchrony persists in response to perturbations to sleep homeostasis or respiration. Using male and female P12 rats, we investigated the coupling strength between the frontal cortex and PZ in response to a short but intense period of sleep deprivation. During recovery sleep, we observed similar rebounds in delta power in PZ and cortex, even in the absence of increased QS duration. Analyses of phase-locking and lagged cross-correlation revealed persistent temporal coupling between the two rhythms such that cortical delta reliably lagged PZ delta regardless of changes in sleep pressure. Curiously, we also observed an increase in the depth of breathing during recovery sleep, which we confirmed in a separate cohort of pups. Next, using moderate hypercapnia (5% CO
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