ArticleImmunity2026
Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4
Abstract read
In one paragraph
Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
11 authors.
Atishay JayDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Bioengineering, University of Pennsylvania School of Engineering and Applied Science, Philadelphia, PA, USA.
Yeqiao ZhouEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sora YoonDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Bereketab N AbejeDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Aditi ChandraDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Michael F MichielettoInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Julia WaldDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Bioengineering, University of Pennsylvania School of Engineering and Applied Science, Philadelphia, PA, USA.
Jorge Henao-MejiaInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Arjun RajDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Bioengineering, University of Pennsylvania School of Engineering and Applied Science, Philadelphia, PA, USA.
Robert B FaryabiInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: faryabi@pennmedicine.upenn.edu.
Golnaz VahediDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: vahedi@pennmedicine.upenn.edu.
Funding
3-Dimensional genomic architecture in innate lymphoid cells and allergic inflammationR01AI168240 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENAO-MEJIA, JORGE, VAHEDI, GOLNAZ · 2022 to 2025
$3.2M3D genome organization of the Ets1-Fli1 locus controls allergic responsesR01AI168136 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Jorge Henao-Mejia, Golnaz Vahedi · 2023 to 2026
$3.1MEpigenetic Mechanisms Underpinning Mantle Cell Lymphoma Sensitivity and Resistance to Notch InhibitorsR01CA248041 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert Babak Faryabi · 2022 to 2026
$2.1MNCI NIH HHS R01 CA248041NIAID NIH HHS R01 AI168136NIAID NIH HHS R01 AI168240
Abstract
Naive CD4
Indexed as
CD4-Positive T-LymphocytesChromatinCytokinesSuper EnhancersAllelesAnimalsCCCTC-Binding FactorEnhancer Elements, GeneticGene Expression RegulationMiceMice, Inbred C57BLProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-fli-1Th1 CellsThymocytesCCCTC-Binding FactorChromatinCtcf protein, mouseCytokinesEts1 protein, mouseFli1 protein, mouseProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-fli-1chromatin tracingcytokinesenhancersETS1FLI1gene dosagemicroscopyparalogous transcription factorsT cellsT helper cells
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.