Evidence map›Paper›PMID 42636800›Full record

ArticleCell reports. Medicine2026

Spatiotemporal iron-hijacking hydrogel reprograms host-pathogen iron homeostasis for fungal keratitis therapy.

Jian He, Yang Ye, Hongxia Yuan, Jiahua Niu, Dongxiao Zhang, Fuyao Chen, Qing Zhang, Jiancheng Liang, Zhongshu Wu, Ke Yao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian HeEye Center, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310009, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining 314400, China.
Yang YeEye Center, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310009, China.
Hongxia YuanZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining 314400, China.
Jiahua NiuZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining 314400, China.
Dongxiao ZhangDepartment of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310000, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou, Hangzhou 310000, China.
Fuyao ChenEye Center, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310009, China.
Qing ZhangZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining 314400, China.
Jiancheng LiangGraduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo, Tokyo 113-8657, Japan.
Zhongshu WuZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining 314400, China.
Ke YaoEye Center, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: xlren@zju.edu.cn.
Min ZhouEye Center, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310009, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining 314400, China; State Key Laboratory of Transvascular Implantation Devices, Zhejiang University, Hangzhou 310009, China. Electronic address: zhoum@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe infections caused by opportunistic fungal pathogens like Candida albicans remain a major clinical challenge, exemplified by vision-threatening fungal keratitis (FK). Targeting host-pathogen iron competition offers a promising antifungal strategy. Here, we identify a vicious cycle in human FK, where iron overload-driven host ferroptosis promotes fungal proliferation and inflammation. To disrupt this, we develop a spatiotemporally controlled gallium-deferiprone (Ga-DFP) composite hydrogel (PGaDH) that reprograms host-pathogen iron homeostasis through an iron-hijacking strategy. Specifically, PGaDH enables rapid DFP release to induce fungal iron starvation and activate iron acquisition pathways, followed by slow Ga

Indexed as

Eye Infections, FungalHomeostasisHost-Pathogen InteractionsHydrogelsIronKeratitisAnimalsAntifungal AgentsCandida albicansDeferiproneGalliumHumansMiceOxidative StressRabbitsAntifungal AgentsDeferiproneGalliumHydrogelsIronenergy metabolismferroptosisfungal keratitisgalliumhost-pathogeniron hijackingiron homeostasisocular retentionspatiotemporal releasethermosensitive hydrogel

Identifiers

PMID42636800
PMCPMC13589488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.