Evidence map›Paper›PMID 42636796›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2026

Factors associated with viral suppression and antiretroviral therapy adherence among adolescents and young adults living with HIV in the African Cohort Study.

Marie A Brault, Aima A Ahonkhai, Seth Frndak, Susannah Colt, Trevor A Crowell, Ajay Parikh, Emma R Duff, Valentine Sing'oei, John Owuoth, Jonah Maswai and 7 more

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In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marie A BraultNew York University Grossman School of Medicine, Institute for Excellence in Health Equity, New York, NY USA.ORCID 0000-0002-7152-785
Aima A AhonkhaiMassachusetts General Hospital, Harvard University Center for AIDS Research, Boston, MA, USA.ORCID 0000-0003-0666-4767
Seth FrndakU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-2049-2204
Susannah ColtU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Trevor A CrowellU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ajay ParikhU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Emma R DuffU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Valentine Sing'oeiWalter Reed Army Institute of Research - Africa, Kisumu, Kenya.
John OwuothWalter Reed Army Institute of Research - Africa, Kisumu, Kenya.
Jonah MaswaiU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Zahra ParkerU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Emmanuel BahemanaU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Hannah KibuukaMakerere University-Walter Reed Program, Kampala, Uganda.
Sten H VermundUniversity of South Florida College of Public Health, Tampa FL, USA.ORCID 0000-0001-7289-8698
Neha ShahU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Julie A AkeU.S. Military HIV Research Program, Center for Infectious Disease Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-3831-5828
AFRICOS Study Group

Funding

Understanding Pandemic Evolution through Networked Data (UPEND)RF1MH133442 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI CROWELL, TREVOR ADAM · 2023 to 2023
$3.8M
Engaging providers, community members, and young women to adapt and pilot a youth-friendly sexual and reproductive health package in low-income communities in IndiaK01TW011480 · FIC · YALE UNIVERSITY · PI BRAULT, MARIE AMANDA · 2020 to 2023
$591k
FIC NIH HHS K01 TW011480NIMH NIH HHS RF1 MH133442
6 · The paper itself

Abstract

introductionAdolescents and young adults living with HIV (AYLHIV) experience poor outcomes across the care continuum, and most reside in sub-Saharan Africa. The African Cohort Study (AFRICOS) provides an opportunity to examine HIV outcomes in this population across Kenya, Nigeria, Tanzania, and Uganda.

methodsWe conducted a cross-sectional analysis of AYLHIV aged 15-29 years, enrolled in AFRICOS 2013-2023, and on antiretroviral therapy (ART) ≥ six months. Primary outcomes were HIV viremia and 30-day ART non-adherence. Factors included HIV acquisition route, ART duration, ART class, and site. We used multivariate robust Poisson regression to estimate relative risks (RRs) and 95% confidence intervals (CIs). Site directors were surveyed to assess youth-friendly services.

resultsAmong 656 participants, the median age was 20.0 years (IQR 17.5-23.3); 41.6% were male, 61.6% had perinatally-acquired HIV, and median duration since HIV diagnosis was nine years. At enrollment, 83.8% had viral suppression (<200 copies/mL) and 80.2% were ART adherent. ART regimen and clinic site were associated with viral suppression: youth on integrase vs. protease inhibitor-based regimens (adjusted relative risk (aRR) 0.38, CI 0.23-0.63, p<0.001), and in Uganda (aRR 0.42, CI 0.20-0.90, p=0.026) or Kisumu, Kenya (aRR 0.40, CI 0.22-0.76, p=0.005) had lower likelihood of non-suppression. Compared to Nigeria, participants from other sites were less likely to report non-adherence (unadjusted RR 0.31-0.44). Youth-friendly service provision varied.

conclusionsViral suppression and ART adherence were high among AYLHIV in AFRICOS. Clinic site and ART regimen were associated with outcomes, highlighting the importance of health system factors.

Indexed as

Adolescents and young adultsART adherenceHIVKenyaNigeriaTanzaniaUgandaviral load suppression

Identifiers

PMID42636796
PMCPMC13634597

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.