Evidence map›Paper›PMID 42636458›Full record

ArticleExperimental physiology2026

Thermoregulatory and plasma neurobiomarker responses to heat tolerance assessment in exertional heat illness and matched controls.

Tom W Palin, Jo Corbett, Lisa J Hill, David R Woods, Alex A M Gould, Barney Wainwright, James A Roberts, Chloe N Thomas, Daniel Snape, Carol House and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tom W PalinCarnegie School of Sport, Leeds Beckett University, Leeds, UK.ORCID https://orcid.org/0009-0009-0540-4761
Jo CorbettExtreme Environments Laboratory, School of Psychology, Sport, and Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.ORCID https://orcid.org/0000-0002-6552-6471
Lisa J HillDepartment of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
David R WoodsCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
Alex A M GouldExtreme Environments Laboratory, School of Psychology, Sport, and Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Barney WainwrightCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
James A RobertsDepartment of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Chloe N ThomasDepartment of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-6202-1347
Daniel SnapeCarnegie School of Sport, Leeds Beckett University, Leeds, UK.ORCID https://orcid.org/0000-0002-9916-7390
Carol HouseExtreme Environments Laboratory, School of Psychology, Sport, and Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Omar TayariSurvival and Thermal Medicine Department, Institute of Naval Medicine, Gosport, UK.
Richard J ElsworthySchool of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
James L MitchellDepartment of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Andrew J RobertsArmy Recruit Health and Performance Research, Medical Branch, HQ Army Recruiting and Initial Training Command, Ministry of Defence, Upavon, UK.ORCID https://orcid.org/0000-0003-1709-0826
John P O'HaraCarnegie School of Sport, Leeds Beckett University, Leeds, UK.ORCID https://orcid.org/0000-0003-1589-7984
Michael J StaceyCarnegie School of Sport, Leeds Beckett University, Leeds, UK.

Funding

Ministry of Defence
6 · The paper itself

Abstract

Exercise in the heat and elevated tissue temperature are associated with neuronal stress and changes in blood-brain barrier (BBB) function. More severe thermal insult may manifest as exertional heat illness (EHI) and complication by central nervous system (CNS) dysfunction may persist post-EHI. We investigated neurobiomarkers associated with neuronal injury (brain-derived tau, BD-tau; neurofilament light, NfL; ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1) and BBB function (glial fibrillary acid protein, GFAP) in the peripheral blood of 34 recent (∼4 months) EHI patients and 30 Control individuals without prior EHI history, matched for variables influencing thermoregulation. Participants completed an exercise heat tolerance assessment (HTA), with neurobiomarkers measured pre- and post-HTA. An equal number of participants (n = 6) in both EHI and Control groups showed thermoregulatory responses consistent with thermal intolerance. Pooled changes in BD-tau, GFAP and UCH-L1 showed moderate to large effect sizes (Cohen's d = 1.2, -1.3 and 0.75, respectively), including novel elevation in BD-tau (median [interquartile range] 4.84 [4.10, 5.51] vs. 6.89 [5.69, 7.85] pg mL

Indexed as

blood–brain barrierbrain‐derived tauheat stroketraumatic brain injury

Identifiers

PMID42636458
PMCPMC13502995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.