Evidence map›Paper›PMID 42636380›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion.

Cyril Bolduc, Cameron Oram, Skylar Donovan, Haleigh Bach, Martha Liu, Rafaëlle Marier, Morgan Sharpe, Siqi Liu, Cédric Campeau, Carl Duncan Spencer and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cyril BolducDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0003-6104-8462
Cameron OramDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0003-2778-6031
Skylar DonovanDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0005-1592-1237
Haleigh BachDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.
Martha LiuDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0006-6833-8720
Rafaëlle MarierDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.
Morgan SharpeDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0001-6537-0489
Siqi LiuDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0006-9338-2280
Cédric CampeauDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0003-0435-4244
Carl Duncan SpencerDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0009-0008-5562-4861
Sarah A MartinDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.
Rajeshwar AwatramaniDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-0713-2140
Jean-François PoulinDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Quebec.ORCID 0000-0002-1039-4985

Funding

Canadian Institutes of Health Research (CIHR) NACanadian Institutes of Health Research (CIHR) PJT-183760Fonds de recherche du Québec (FRQ) NAParkinson Canada (parkinsoncan) NA
6 · The paper itself

Abstract

Despite advances in delineating the molecular diversity and projection patterns of midbrain dopamine (DA) neurons, subtype-specific contributions to motor learning and movement execution remain poorly defined. Here, we applied intersectional ablation and inhibitory chemogenetics to dissect the roles of calbindin-expressing (CALB1

Indexed as

Calbindin 1CalbindinsDopaminergic NeuronsLocomotionMesencephalonAnimalsDopamineMaleMiceCalb1 protein, mouseCalbindin 1CalbindinsDopaminebasal gangliabradykinesiadopamine subtypesexplorationfiberphotometry

Identifiers

PMID42636380
PMCPMC13535173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.