Evidence map›Paper›PMID 42636370›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Histone modification cross talk between a host and pathogen.

Shantinique S Miller, Joel A Hrit, Scott B Rothbart, Evan J Worden

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shantinique S MillerDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503.ORCID 0000-0002-2021-0633
Joel A HritDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503.ORCID 0000-0002-4497-956X
Scott B RothbartDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503.ORCID 0000-0003-1631-5392
Evan J WordenDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503.ORCID 0000-0003-0644-166X

Funding

Molecular mechanisms of chromatin signaling and epigenetic regulationR35GM152184 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Scott Rothbart · 2024 to 2026
$1.6M
Mechanisms of histone crosstalk with bacterial pathogensR21AI173758 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI WORDEN, EVAN J · 2023 to 2024
$523k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 5R21AI173758HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM152184NIAID NIH HHS R21 AI173758NIGMS NIH HHS R35 GM152184
6 · The paper itself

Abstract

Bacterial pathogens modulate host cell physiology by secreting effector proteins that rewire host signaling pathways. A subset of these effectors directly modify host chromatin to reprogram gene expression and promote infection. While these enzymes are thought to function autonomously, the extent to which the host epigenetic landscape regulates their activity remains largely unknown. RomA and its homolog LegAs4 are Set domain-containing lysine methyltransferases from

Indexed as

Bacterial ProteinsHistone CodeHistonesHost-Pathogen InteractionsLegionella pneumophilaProtein Processing, Post-TranslationalAcetylationEpigenesis, GeneticHistone-Lysine N-MethyltransferaseHumansMethylationBacterial ProteinsHistone-Lysine N-MethyltransferaseHistoneschromatineffectorepigenetichistonepathogen

Identifiers

PMID42636370
PMCPMC13534545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.