Evidence map›Paper›PMID 42636309›Full record

ArticleCirculation2026

Spatial and Single-Nucleus Multiomics Profiling Reveals Heterogeneous Endothelial Cell Overabundance in Endocardial Fibroelastosis.

Yang Yu, Gaopeng Xian, Shaila Saifee, Michael Trembley, Kulandaisamy Arulsamy, Yanqiang Li, Shenli Yuan, Min Chen, Yapeng Liu, Jiehui Chen and 13 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

23 authors.

Yang Yu *Departments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-2870-5729
Gaopeng Xian *Departments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Shaila SaifeeDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0009-0003-1616-0180
Michael TrembleyDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0001-6675-9325
Kulandaisamy ArulsamyDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-3367-2669
Yanqiang LiDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0001-6846-6884
Shenli YuanDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0009-0009-7137-8098
Min ChenDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0003-0521-7172
Yapeng LiuDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Jiehui ChenDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-0550-2195
Yunxia WangDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Yi WangDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-0291-5314
Rongbin ZhengDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Xinlei GaoDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Dean LiDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Jiayi ChenDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.
Ingeborg FriehsCardiac Surgery (I.F., P.D.N.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-2631-2972
Pedro Del NidoCardiac Surgery (I.F., P.D.N.), Boston Children's Hospital, Boston, MA.ORCID 0000-0003-4252-8789
Stephen P SandersDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0003-3521-4044
Chrystalle Katte CarreonPathology (C.K.C.), Boston Children's Hospital, Boston, MA.ORCID 0000-0003-2152-7998
William T PuDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-4551-8079
Kaifu ChenDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0003-1009-4357
Lili ZhangDepartments of Cardiology (Y.Y., G.X., S.S., M.T., K.A., Y. Li, S.Y., M.C., Y. Liu, Jiehui Chen, Yunxia Wang, Yi Wang, R.Z., X.G., D.L., Jiayi Chen, S.P.S., W.T.P., K.C., L.Z.), Boston Children's Hospital, Boston, MA.ORCID 0000-0002-5032-7031

Funding

Reversal of Heart Failure: Role of Vascular RecoveryR01HL148338 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2020 to 2023
$2.8M
Transcription Factor 4 Maintain Endothelial identity to Oppose Heart FailureR01HL155632 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Lili Zhang · 2022 to 2026
$2.5M
A novel role for EZH2 in A-to-I RNA editing in prostate cancerR01CA278832 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Qi Cao, Kaifu Chen · 2024 to 2026
$2.0M
Bioinformatics Techniques to Analyze Dynamic Changes of 3D GenomeR01GM138407 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CHEN, KAIFU · 2022 to 2025
$1.8M
Role of S-nitrosylation in TransdifferentiationR01HL133254 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2018 to 2021
$1.6M
Computational epigenetics modeling of cell identity genesR01GM125632 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU · 2018 to 2021
$1.4M
Modulating Endothelial Inflammatory Activation for Atherosclerosis TreatmentR01HL185185 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Lili Zhang · 2026 to 2026
$687k
Computational Technology for Single-Cell Functional GenomicsK99HG013662 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI Rongbin Zheng · 2025 to 2026
$261k
NCI NIH HHS R01 CA278832NHGRI NIH HHS K99 HG013662NHLBI NIH HHS R01 HL133254NHLBI NIH HHS R01 HL148338NHLBI NIH HHS R01 HL155632NHLBI NIH HHS R01 HL185185NIGMS NIH HHS R01 GM125632NIGMS NIH HHS R01 GM138407
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

endocardial fibroelastosisendothelial cellshypoplastic left heart syndromemultiomicsspatial transcriptomics

Identifiers

PMID42636309
PMCPMC13505504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.