Evidence map›Paper›PMID 42636254›Full record

ArticleJNCI cancer spectrum2026

Evaluating the impact of virtual oncology financial and legal navigation on cancer-related financial toxicity.

Jean S Edward, Lynn J Andreae, Haafsah Fariduddin, Elizabeth Ruschman, Lori Eisele, Mackenzie Caldwell, Joanna Doran, Monica Bryant, Jordan Heflin, Brent Shelton and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in JNCI cancer spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07409662 (Coverage and Cost of Care Links- Telehealth), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07409662 nacompletednot on this map

Coverage and Cost of Care Links- Telehealth

TypeinterventionalSponsorJean EdwardRan2024 to 2025Enrolled124ConditionsFinancial Stress, Hematologic Cancer, SurvivorshipArmsCC LinksTele
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jean S EdwardSchool of Nursing, University of Louisville, Louisville, KY, United States.ORCID 0000-0001-9184-1048
Lynn J AndreaeCenter for Health, Engagement, and Transformation, College of Medicine, University of Kentucky, Lexington, KY, United States.
Haafsah FariduddinCollege of Medicine, University of Kentucky, Lexington, KY, United States.
Elizabeth RuschmanCollege of Medicine, University of Kentucky, Lexington, KY, United States.
Lori EiseleSchool of Nursing, University of Louisville, Louisville, KY, United States.
Mackenzie CaldwellCollege of Medicine, University of Kentucky, Lexington, KY, United States.
Joanna DoranTriage Cancer, Chicago, IL, United States.
Monica BryantTriage Cancer, Chicago, IL, United States.ORCID 0009-0003-7183-4467
Jordan HeflinDepartment of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY, United States.
Brent SheltonBrown Cancer Center, University of Louisville, Louisville, KY, United States.
John D'OrazioDepartment of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY, United States.
Kimberly D NorthripDepartment of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY, United States.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Kentucky Cabinet for Health and Family ServicesKentucky Pediatric Cancer Research Trust FundNCI NIH HHS P30 CA177558
6 · The paper itself

Abstract

purposeTo evaluate the impact of a virtual oncology financial and legal navigation (OFLN) intervention on cancer-related financial toxicity (FT) and health-related quality of life (QOL) in pediatric and adolescent and young adult (PAYA) cancer patients and caregivers, as well as to assess the intervention's acceptability and feasibility.

methodsA single-arm trial was conducted in a PAYA oncology clinic between March 2024 and May 2025. Pre- and post-intervention surveys included the Comprehensive Score for Financial Toxicity (COST), Patient-Reported Outcomes Measurement Information System global health, anxiety and depression scales, National Comprehensive Cancer Network's Distress Thermometer, and intervention acceptability, appropriateness, and feasibility of measures.

resultsThe majority (36 patients and 88 caregivers) identified as female (73%), non-Hispanic White (85%), rural residents (61%), with incomes above the federal poverty level (71%). Participants reported moderate levels of FT at baseline with a mean COST of 20.9 (SD = 11.14) for patients and 19.3 (SD = 10.12) for caregivers and high levels of anxiety, depression, and distress. Among caregivers, there was a significant (P = .01) post-intervention increase in COST (indicating decreased FT). Almost all patients reported decreases in subjective stress and anxiety (94%) and feeling better prepared to navigate financial/legal issues. Participants rated the intervention highly across implementation outcomes of acceptability (76%), appropriateness (76%), and feasibility (75%), which was also supported by 89% enrollment and 95% retention rates.

conclusionFindings demonstrate that virtual OFLN has the potential to increase access to supportive care services, especially in rural communities. Additional research supporting scalability and uptake for widespread implementation is needed. ClinicalTrials.gov ID: NCT07409662.

Indexed as

CaregiversCost of IllnessFinancial StressMedical OncologyNeoplasmsQuality of LifeAdolescentAdultAnxietyChildDepressionFeasibility StudiesFemaleHumansMaleMiddle Aged

Identifiers

PMID42636254
PMCPMC13637623

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.