Evidence map›Paper›PMID 42636038›Full record

ArticleeLife2026

Optimising the tilt increment for in situ cryo-electron tomography.

Maarten Willem Tuijtel, Tomáš Majtner, Beata Turoňová, Martin Beck

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maarten Willem TuijtelDepartment of Molecular Sociology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-0615-572X
Tomáš MajtnerDepartment of Molecular Sociology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-5279-8806
Beata TuroňováDepartment of Molecular Sociology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-5457-4478
Martin BeckDepartment of Molecular Sociology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-7397-1321

Funding

Chan Zuckerberg Initiative 2021-234666Deutsche Forschungsgemeinschaft SFB1507 Project No. 450648163
6 · The paper itself

Abstract

Cryo-electron tomography (cryo-ET) enables high-resolution, three-dimensional imaging of cellular structures in their native, frozen state. However, image quality is limited by a trade-off between angular sampling and radiation damage. Therefore, the choice of the angular increment during data collection is a critical parameter that affects tomogram quality and downstream analyses. Optimising this increment is challenging due to the high demands on microscope time, storage, and computation. In this study, we systematically evaluated tilt increments of 1°, 2°, 3°, 5°, and 10° using lamellae from

Indexed as

Cryoelectron MicroscopyDictyosteliumElectron Microscope TomographyImaging, Three-DimensionalImage Processing, Computer-Assistedcryo-electron tomographydictyosteliummolecular biophysicsstructural biologysubtomogram averaging

Identifiers

PMID42636038
PMCPMC13502964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.