Evidence map›Paper›PMID 42635938›Full record

ArticleCell biochemistry and biophysics2026

Comparative Efficacy of Coriander Seed Extract-Loaded Selenium Nanoparticles and DMSA in Restoring Antioxidant/Apoptotic Balance of Lead-Induced Hepatotoxicity.

Eslam Elshaier, Abdel Ghany F Shoair, Rehab Reda Hassan, Mansour Emad, Noureen ELKattan, Ahmed Khalifa, Mohamed Essam, M M Farag, Fayez Althobaiti, Marwa M M Fawzy and 1 more

Abstract readComparative Study
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In one paragraph

Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eslam ElshaierFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Abdel Ghany F ShoairDepartment of Science and Technology, University College-Ranyah, Taif University, Taif, 21975, Saudi Arabia.
Rehab Reda HassanFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Mansour EmadFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Noureen ELKattanFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Ahmed KhalifaFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Mohamed EssamFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
M M FaragBiochemistry Department, Faculty of Medicine, Taif University, Taif, Saudi Arabia.
Fayez AlthobaitiDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Marwa M M FawzyDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha, Egypt.
Heba A SahyonFaculty of Science, Chemistry Department, Biochemistry Program, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt. heba_sahuon@sci.kfs.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead (Pb) is a heavy metal that causes hepatotoxicity even in trace amounts. This study investigated the therapeutic potential of coriander extract-loaded selenium nanoparticles (coriander@Se-NPs) against Pb toxicity in a mouse model, comparing its efficacy to the benchmark standard chelator, DMSA. The effectiveness of coriander extract, coriander@Se-NPs, and synthetic chelator (DMSA) was evaluated. The study groups contain: a control group receiving distilled water, a Pb toxicity group given Pb-acetate at 150 mg/kg, a positive control group treated with DMSA after Pb exposure, and two groups receiving coriander extract or coriander@Se-NPs after Pb exposure, both at 200 mg/kg daily for three weeks. Our results demonstrated that the coriander@Se-NPs significantly reduced hepatic Pb concentrations (83.90%) and restored antioxidant enzyme activities (SOD and CAT) more effectively than DMSA. Notably, coriander@Se-NPs exhibited potent anti-inflammatory and anti-apoptotic effects, evidenced by a 12.5-fold reduction in IL-6 and the suppression of Caspase 3 to sub-normal levels (0.399-fold). Furthermore, the coriander@Se-NPs treatment stabilized Beclin 1 levels, suggesting a restoration of cellular autophagy homeostasis. These findings indicate that coriander@Se-NPs provide a superior, multi-modal protective shield against heavy metal poisoning compared to traditional synthetic chelators, DMSA, highlighting their potential as a high-efficacy nanomedicine for clinical toxicology. Further studies are needed to explore its potential clinical applications and mechanisms.

Indexed as

AntioxidantsApoptosisCoriandrumLeadMetal NanoparticlesNanoparticlesPlant ExtractsSeleniumSuccimerAnimalsBeclin-1Caspase 3CatalaseChelating AgentsInterleukin-6LiverAntioxidantsBeclin-1Caspase 3CatalaseChelating AgentsInterleukin-6LeadPlant ExtractsSeleniumSuccimerSuperoxide DismutaseBCL-2Coriander extractDMSA, Beclin 1Selenium nanoparticle

Identifiers

PMID42635938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.