Observational studyJournal of endocrinological investigation2026
Muscle strength and HbA1c in geriatric patients with and without diabetes: a retrospective observational cohort study.
Observational study in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimHandgrip strength (HGS) is a simple, reliable, and widely used biomarker of muscle strength and a key component in sarcopenia screening. Its potential role as an indicator of glycemic control has attracted increasing interest; however, the relationship between HGS and glycated hemoglobin (HbA1c) in older adults remains insufficiently understood, particularly in populations characterized by frailty and multimorbidity. This study aimed to explore the relationship between HGS and HbA1c levels in older adults with and without diabetes mellitus (DM) and to evaluate the potential of HGS as a clinically informative marker in the assessment of glycemic status within a comprehensive geriatric context.
methodsIn this retrospective study, 573 patients aged ≥ 60 years who underwent Comprehensive Geriatric Assessment (CGA) between May 2023 and October 2025 were included. HGS was measured using a dynamometer, and sarcopenia risk was assessed with SARC-F. Participants were stratified into sex-specific low and high HGS groups. HbA1c levels were compared across groups, and associations were examined using Spearman's correlation and multivariable linear regression analyses with stepwise adjustment for clinically relevant confounders.
resultsThe study population had a median age of 78 years, with a high prevalence of frailty (72.8%) and sarcopenia risk (81.2%). Despite generally low HGS values, individuals in the higher HGS group demonstrated higher HbA1c levels across the overall cohort and SARC-F subgroups (p < 0.05). Correlation analyses showed statistically significant but very weak positive associations between HGS and HbA1c, particularly among individuals at risk of sarcopenia. Although these associations were consistent in direction, their magnitude was limited. Regression analyses showed that this association was maintained in an adjusted model for CCI, Yesavage geriatric depression scale, three-word recall test; however, it was no longer significant in another fully adjusted model for age, BMI, diabetes status, medications, renal function, and nutritional status.
conclusionThe findings indicate that there may be a weak association between HGS and glycemic status in older adults; therefore, they should be interpreted with caution. HGS may provide limited complementary information within a comprehensive geriatric assessment, particularly in frail populations, but its clinical relevance for evaluating glycemic control remains uncertain and warrants further investigation in prospective studies.
Indexed as
Identifiers
42635904What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.